Transparency and Reproducibility of Supplementary Search Methods in Systematic Reviews for NICE Single Technology Appraisals
Systematic reviews (SRs) form an important part of a manufacturer’s submission for the National Institute for Health and Care Excellence (NICE) single technology appraisal (STA) process....
Survival analyses based on data from oncology randomised controlled trials (RCTs) provide key evidence for decision- making on treatment options for cancer. In the second of our DRG investigative...
The Use and Acceptance of the Meta-Analysis of Survival Outcomes to Support Health Technology Assessment Submissions in the UK
National Institute of Health and Care Excellence (NICE) guidelines recommend the use of indirect comparison and network meta-analysis (NMA) when gold standard evidence from head-to-head randomised...
Network Meta-Analysis for Health Technology Submissions Worldwide: A Report Checklist for Best Practice
Network meta-analysis (NMA) is an accepted statistical method used to model the clinical- and cost-effectiveness of treatments in the absence of data from head-to-head randomised controlled trials (...
Network Meta-Analysis in Health Technology Assessment: Novel Approaches for Indirect Evidence Searching
Systematic reviews (SRs) form an important part of a manufacturer’s submission for the National Institute for Health and Care Excellence (NICE) single technology appraisal (STA) process. In the...
Meta-Analysis to Support UK Health Technology Assessment Submissions: A Review of NICE and Evidence Review Group Critiques
The quality of evidence used in manufacturers’ submissions for technology appraisal (TA) is an important factor in receiving a positive recommendation from health technology assessment (HTA) bodies...
Systematic reviews are central to evidence-based medicine and increasingly inform healthcare decision making around the world.
Our multi-disciplinary team of systematic review analysts, statisticians and medical writers has extensive experience in the design, conduct and communication of systematic literature reviews and meta-analyses. We are dedicated to delivering high-quality systematic reviews and statistical analyses, and attention-to-detail and accuracy underpin all that we do. Gathering all the relevant data takes time and energy. We use industry-standard techniques and approaches to ensure we minimize errors and get it 'right first time'; to this end, we have developed customized systematic review software to manage our review data and ensure quality is assured. All of our reviews conform to the current PRISMA guidelines.
Download our white paper series: Fundamentals of Systematic Review and Network Meta-Analysis– how to generate robust evidence?
Systematic review (SR) and network meta-analysis (NMA) are well-established methods of evidence generation which are routinely submitted as part of health technology assessments (HTAs) globally. Despite the availability of international guidelines and best practices for conducting SR and NMA there are many practical challenges which investigators face. DRG Abacus have expertise in conducting a range of different types of SR and NMA and actively conduct independent research into method developments as we strive to improve best practices.
In this series we present papers which highlight a selection of the challenges investigators may encounter when conducting evidence synthesis and report our ongoing active research to address such challenges and promote best practices. These include:
- The transparency and reproducibility of supplementary search methods in systematic reviews conducted for NICE single technology appraisals
- The suitability of survival analyses within randomized controlled trials (RCTs) and the implications for meta-analysis.
- The use and acceptance of the meta-analysis of time-to-event data to support submissions to HTA bodies
- Network meta-analysis in HTAs: novel approaches for searching for indirect evidence
- Network meta-analysis for health technology submissions worldwide: a report checklist for NMA best practices globally
- Meta-analysis to support UK HTA submissions: a review of NICE and Evidence Review Group critiques
This series of papers would be of interest to investigators conducting SR and NMA and more generally those working in health economics and outcomes research.
Systematic review & meta-analysis services include:
- Protocol design
- Design and running of searches
- Data extraction
- Qualitative reporting
- Meta-analysis, including indirect comparisons & network meta-analyses (NMAs) Publications