As the term implies, levodopa-induced dyskinesia (LID) is a complication of chronic use of levodopa, the gold standard of Parkinson’s disease (PD) treatment. Surveyed neurologists estimate that 40% of their patients suffer from LID, which is often disabling and painful, impacting quality of life and increasing fall risk. For decades, the only drug for LID has been immediate-release amantadine—now long generic—but it is not specifically approved for LID and has an unfavorable side-effect profile. Now, the treatment of PD-LID is evolving, thanks to the recent FDA approval of Gocovri for LID and research suggesting Xadago may have a positive impact. Understanding prescriber perceptions of available options and the drivers of clinical decision-making in PD-LID will help drug developers identify levers for new product positioning and differentiation and gauge unmet clinical need for further innovations in this arena.

Questions Answered

  • What clinical end points and drug attributes are most influential in prescribing for PD-LID? How do amantadine, Gocovri, and Xadago perform on these attributes?
  • What are the prevailing areas of unmet need and opportunity in the treatment of PD-LID?
  • Based on conjoint analysis and TPP simulation, what trade-offs between efficacy, safety, and price are neurologists willing to make for a hypothetical new PD-LID drug?

Markets covered: United States, United Kingdom, France, Germany.

Primary research: Survey of 62 U.S. and 30 European neurologists fielded in December 2018.

Key drugs covered: Amantadine, Gocovri, Xadago.

Key metrics included:

  • Target Product Profile (TPP) simulator based on conjoint analysis methodology.
  • Stated versus derived importance of product attributes on prescribing behavior.
  • Assessment of current drug performance against treatment drivers and goals.
  • Physician perceptions of unmet needs in PD-LID and related PD subpopulations.
  • Analysis of remaining drug development opportunities.

Product Description

Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. Two market scenarios are profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.

Table of contents

  • Parkinson's Disease - Unmet Need - Detailed, Expanded Analysis - Levodopa-Induced Dyskinesia (US&EU)

Author(s): Bethany Christmann, PhD

Bethany Christmann, Ph.D., has been with DRG since 2015, and is a Senior Business Insights Analyst with the Central Nervous System/Ophthalmology team. In this role, she covers the neurology space, specializing in Parkinson’s disease and epilepsy; she provides expert insight and authors primary market research and forecasting content focused on these and other neurology indications. Prior to joining DRG, Bethany earned her Ph.D. in neuroscience from Brandeis University, where she studied the cellular interactions involved in memory consolidation and their link to sleep behavior.


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