Depressive episodes are more common than manic episodes in bipolar disorder (BPD) patients. Of note, BPD II is often characterized by a higher frequency of depressive episodes that last longer compared with BPD I. The symptoms of bipolar depression can include fatigue, insomnia, suicidal ideation, and feelings of worthlessness. Only a few drugs are FDA-approved to treat the depressive symptoms of BPD I, and even fewer drugs are approved for BPD II depression (e.g., Intra-Cellular Therapies’ Caplyta, a newer-to-market antipsychotic). In addition, no drug is approved to treat the suicidality in bipolar depression. Notably, European psychiatrists have more-limited treatment options for bipolar depression than U.S. psychiatrists do, and available therapies have their own shortcomings. Given the longer duration for depressive symptoms and the paucity of therapeutic options in this segment, there is substantial need for novel therapies to treat bipolar depression. Understanding the drivers of clinical decision-making in the treatment of bipolar depression and the areas of opportunity will help drug developers prioritize agents that address the indication’s treatment needs and help marketers determine how to leverage their products’ attributes.
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PRODUCT DESCRIPTION
Provides quantitative insight into U.S. and European physician perceptions of key treatment drivers and goals and the current level of unmet need for a specific disease. Commercial opportunities are analyzed, and the extent to which emerging therapies may capitalize on these opportunities is evaluated.
Markets covered: United States, United Kingdom, France, Germany
Primary research: Survey of 61 U.S. and 30 European psychiatrists fielded in June 2023
Key companies: AbbVie, Gedeon Richter, Intra-Cellular Therapies, NeuroRx Pharmaceuticals
Key drugs: Lithium, lamotrigine, quetiapine IR/XR, lumateperone, sertraline, cariprazine, olanzapine/fluoxetine combination, NRX-101