Lennox-Gastaut syndrome (LGS) is a severe, pediatric-onset epilepsy syndrome characterized by developmental delay or regression, multiple seizure types, and electroencephalographic abnormalities. LGS patients have a higher mortality rate than age-matched peers, with seizure complications being a prominent contributing factor. Despite the availability of more than 25 antiepileptic drugs (AEDs), several of which are approved specifically to treat LGS, the majority of LGS patients do not attain adequate seizure control even with chronic polypharmacy. Despite the highly genericized nature of the epilepsy market, opportunity exists for novel branded therapies that offer greater efficacy, safety, and tolerability than approved or commonly prescribed LGS treatment options.

Table of contents

  • Epilepsy - Unmet Need - Detailed, Expanded Analysis: Lennox Gastaut Syndrome

Author(s): John Crowley; Bethany Christmann, PhD

John leads DRG’s Infectious, Niche, & Rare Diseases team and manages the market research portfolio across niche and rare diseases, anti-infectives, and vaccines. Prior to his current role, he was a Director on the team overseeing syndicated and custom work on niche and rare disease markets, as well as atopic dermatitis content in DRG’s Dermatology portfolio. He also served as a DRG analyst in the neurology space, focused mainly on the multiple sclerosis market. John holds a Ph.D. from the University of Massachusetts Medical School and a Bachelor’s degree from Worcester Polytechnic Institute.

Bethany Christmann, Ph.D., has been with DRG since 2015, and is a Senior Business Insights Analyst with the Central Nervous System/Ophthalmology team. In this role, she covers the neurology space, specializing in Parkinson’s disease and epilepsy; she provides expert insight and authors primary market research and forecasting content focused on these and other neurology indications. Prior to joining DRG, Bethany earned her Ph.D. in neuroscience from Brandeis University, where she studied the cellular interactions involved in memory consolidation and their link to sleep behavior.


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