Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the development and progressive enlargement of fluid-filled cysts in the kidneys. Particularly in the early stages, the disease is often asymptomatic and detectable only through diagnostic imaging of the kidney to reveal cysts. The launch of Otsuka’s Jynarque / Jinarc / Samsca (tolvaptan) introduced the first disease-specific therapy for ADPKD. However, several therapies are being investigated in clinical trials, including Sanofi / Genzyme’s venglustat, Reata Pharmaceuticals’ bardoxolone methyl, Palladio Bioscience’s lixivaptan, and Regulus Therapeutics’ RGLS-4326. These therapies are forecast to fulfill several of the unmet needs that remain. These unmet needs include superior efficacy and safety / tolerability compared to tolvaptan, and prescribing to a greater range of patients (e.g., those with elevated liver enzymes).

QUESTIONS ANSWERED

  • What do key opinion leaders think about the emerging therapies Sanofi / Genzyme’s venglustat, Reata Pharmaceuticals’ bardoxolone methyl, Palladio Bioscience’s lixivaptan, Regulus Therapeutics’ RGLS-4326, XORTX Therapeutics’ oxipurinol, and Galapagos’ GLPG2737? What is the likelihood that these drugs will launch? How will emerging therapies differentiate themselves in an increasingly crowded market?
  • How will the anticipated genericization of Otsuka’s Jynarque / Jinarc / Samsca affect the uptake of the branded and emerging therapies?
  • What are the different reimbursement challenges that ADPKD therapies face in the United States, Europe, Japan, and China?
  • What are the key unmet needs in ADPKD, and how likely are they to be met?

Geographies:

  • United States, EU5, Japan, China

Primary research:

  • 20 country-specific interviews with thought-leading nephrologists
  • Supported by survey data collected for this and other DRG research

Epidemiology

  • Diagnosed, and drug-treated prevalent cases of ADPKD by country.

Forecast

  • 15-year, annualized, drug-level sales and patient share of key ADPKD therapies through 2020, segmented by brands / generics and epidemiological subpopulations.

Emerging therapies

  • Phase III/PR: 3 drugs; Phase I/II: 3 drugs

PRODUCT DESCRIPTION

Special Topic: Market Assessment & Forecast provides market intelligence with world-class epidemiology, insight into current and future treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Table of contents

  • Polycystic Kidney Disease - Special Topics - Special Topic: Quantitative Physician Insights - US, EU5, Japan, China
    • Special Topic: Quantitative Physician Insights - US, EU5, Japan, China

Author(s): David Rees, Ph.D.; Graeme Green, Ph.D., M.Sc.

David Rees, M.Biochem., Ph.D., is a senior analyst on the Cardiovascular, Metabolic, Renal, and Hematologic (CMRH) Disorders team at Clarivate. He has authored reports on osteoporosis, pulmonary hypertension, and type 2 diabetes. Previously, he was a postdoctoral research associate at Imperial College London and the Institute of Cancer Research. For his doctoral research, he studied the structures of molecular machines in the Nobel Prize-winning laboratory of Prof. Sir John Walker at the University of Cambridge. Dr. Rees earned his undergraduate degree at the University of Bath.

Graeme Green, M.Sc., Ph.D., is a senior director on the Cardiovascular, Metabolic, Renal, and Hematologic Disorders team at Clarivate. In addition to his extensive market knowledge, he has vast experience delivering and managing syndicated and custom projects. Using various forecasting methodologies, he has authored indication-specific reports and provided assessments on market dynamics, drug development, and corporate strategy. Previously, he worked for a financial management consultancy. Dr. Green studied at King’s College London and holds a Ph.D. in molecular medical microbiology and an M.Sc. in forensic science.