Alopecia areata (AA) is an inflammatory autoimmune skin disease characterized by varying degrees of hair loss. The host immune system targets anagen hair follicles. The primary goal of treatment is to stimulate hair growth through the alleviation of inflammation at sites of hair loss. Topical corticosteroids and topical contact allergens are commonly prescribed for AA; however, tolerability issues, side effects, and the modest efficacy of these treatments underscore the substantial unmet clinical need in AA. The AA pipeline is active, consisting primarily of targeted immunomodulatory agents, and boasts several marketed and investigational JAK inhibitors (e.g., Eli Lilly’s Olumiant, Pfizer’s ritlecitinib, Concert’s CTP-543). This report provides an analysis of AA epidemiology, current disease management, unmet needs, and the clinical and commercial potential of emerging AA therapies.

QUESTIONS ANSWERED

  • How large is the diagnosed AA population, and how will its size change between 2019 and 2029? How large are the diagnosed alopecia totalis and universalis populations?
  • What are the key unmet clinical needs in AA, and to what degree will they be fulfilled by 2029?
  • What is the current state of treatment in AA, and how will it evolve over time?
  • What emerging AA therapies are viewed by treating dermatologists as most promising, and what sales/uptake will they achieve in AA? How will JAK inhibitors fit into the AA treatment algorithm?

CONTENT HIGHLIGHTS

  • Geographies: United States and EU5.
  • Primary research: Six country-specific interviews with thought-leading dermatologists supported by survey data collected for this study.
  • Epidemiology: Diagnosed and drug-treated prevalence of AA by country.
  • Forecast: Drug-level sales and patient share of key AA therapies in 2029.
  • Emerging therapies:
    • Phase II/III: 4 drugs.
    • Phase II: 4 drugs.
    • Coverage of select preclinical and Phase I products.

PRODUCT DESCRIPTION

Niche & Rare Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Table of contents

  • Alopecia - Landscape & Forecast - Disease Landscape & Forecast

Author(s): Sonal Divekar; Stephanie Niquita

Sonal Divekar is an analyst on DRG’s Infectious, Niche & Rare Diseases team, covering diverse indications across the niche & rare portfolio. Prior to this role, she was working as a Senior Analyst at Merck’s Global Centre for Analytics and Forecasting. Her role focused on creating Long Range Forecasts and Demand Forecasts for therapeutic areas like Diabetes and Immunology for the European market. She holds a Master’s degree in Marketing Management from Symbiosis Institute of Business Management, India and a Master’s degree in Microbiology from Pune University, India.

Stephanie Niquita works as an associate epidemiologist at Decision Resources Group. Stephanie holds a masters in public health specializing in epidemiology from TISS, Mumbai and a medical degree from Hubei University of Chinese Medicine, People’s Republic of China. She has been trained as a community physician and has also supervised and coordinated various governmental and non-governmental public health projects.