Alopecia areata (AA) is an inflammatory autoimmune skin disease characterized by varying degrees of hair loss due to the targeting of anagen hair follicles by the host immune system. The primary goal of treatment is to stimulate hair growth through the alleviation of inflammation at sites of hair loss. Topical corticosteroids and topical contact allergens are commonly prescribed; however, tolerability issues, side effects, and the modest efficacy of these treatments underscore the substantial unmet clinical need in AA. The drug development pipeline is active and consists primarily of targeted immunomodulatory agents, with some investigational Janus-activated kinase (JAK) inhibitors (e.g., Pfizer’s ritlecitinib, Concert’s CTP-543) and one recently approved JAK inhibitor (Eli Lilly’s Olumiant [baricitinib]). This report provides an analysis of AA epidemiology, current disease management, unmet needs, and the clinical and commercial potential of emerging therapies.
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Niche & Rare Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.