Huntington’s Disease – Landscape & Forecast – Disease Landscape & Forecast
Huntington’s disease (HD) is a rare progressive neurological disorder characterized by movement disorders, cognitive decline, behavioral changes, and psychiatric disturbances. Current treatment is entirely dependent on symptomatic therapies and includes a cocktail of antidepressants, antipsychotics, and antiepileptics to control patients’ cognitive, behavioral, and neurological symptoms. Treatment for chorea is limited to tetrabenazine and Teva’s Austedo (deutetrabenazine), which launched in 2017 in the United States. HD is a debilitating condition, and available treatments are only marginally effective, leaving tremendous need for effective disease-modifying therapies (DMTs). Ionis/Roche’s HTTRx/RG6042 is an antisense oligonucleotide being evaluated in Phase III trials for HD. The therapy has the potential to modify disease course and, accordingly, has garnered interest among treating physicians. Furthermore, the Phase II HD pipeline also includes a variety of additional symptom-targeting and potential disease-modifying therapies, any of which stands to capitalize on the significant commercial opportunity in HD if its efficacy is demonstrated.
Questions Answered
- How large is the diagnosed Huntington’s population in the United States and EU5? How will the population change by 2029?
- What is the current treatment landscape in Huntington’s disease, and how will it change in the next ten years?
- What do key opinion leaders view as the greatest unmet medical needs in the management of Huntington’s disease?
- What do neurologists consider the most promising emerging therapies for HD to be, and which are likely to launch by 2029?
Product Description
Niche & Rare Disease Landscape & Forecast: comprehensive market intelligence providing world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.
Table of contents
- Huntington's Disease - Landscape & Forecast - Disease Landscape & Forecast
- COVID-19
- Key Findings
- Commercial Outlook
- Forecast
- Etiology and Pathophysiology
- Epidemiology
- Current Treatment
- Unmet Need Overview
- Emerging Therapies
- Access & Reimbursement Overview
- Methodology
- Bottom-Up Forecasting Overview
- Bottom-Up Forecast Assumptions
- General Sources of Data
- Drug-Treatment Rate Assumptions in Huntington's Disease
- Patient-Share Assumptions in Huntington's Disease
- General Statements About Pricing
- Sources for Drug Prices
- 2019 Exchange Rates
- Price per Treated Day: 2019
- Price per Treated Day: 2029
- Dosing, Days of Therapy, and Compliance
- Generic Erosion
- Out-Year Forecasting
- Emerging Therapy Prices
- Primary Market Research
- Appendix
- COVID-19
Raina Priyadarshini, Ph.D., Lead Healthcare Research & Data Analyst, Infectious, Niche, and Rare Diseases. Dr. Priyadarshini trained as a molecular biologist; her research focused on the interplay between tumor suppressor proteins and oncoproteins. She received her doctorate from the National Institute of Immunology in New Delhi, India.