Primary sclerosing cholangitis (PSC) is a chronic, idiopathic cholangiopathy that can progress to cirrhosis, end-stage liver disease, hepatobiliary cancer, and/or colon cancer. The median age of diagnosis is 42 years, and it is more common in men than in women. Despite the severity of PSC, no therapies are approved to treat it. Current treatment with UDCA and fenofibrates offers some clinical benefit but does not prevent the progression to liver cirrhosis or cholangiocarcinoma. However, several therapies with novel mechanisms of action are in development to treat PSC and will be used first line if they prove safe and efficacious. These therapies will capitalize on the immense unmet need in this space.
- What are the key areas of unmet need and opportunity in the PSC therapy market?
- What is the prevalence of PSC in the United States?
- How are PSC patients currently treated in the United States?
- What therapies are in development for PSC?
- How does each current and future player influence the market, and how will this scenario change in the future?
- What are the key drivers and limiters of the PSC therapy market?
- Geography: United States
- Primary Research: Three KOL interviews in December 2019
- Key Companies Covered: Cymabay, Gilead, Intercept Pharmaceuticals, Dr. Falk Pharma, High Tide Biopharma, Acorda Therapeutics, Immunic
- Drugs Covered: Seladelpar, cilofexor, norursodeoxycholic acid, Ocaliva, HTD 1801, timolumab, vidofludimus calcium
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- Primary Sclerosing Cholangitis - Executive Insights - Executive Insights (US)
- Primary Sclerosing Cholangitis Executive Insights
Author(s): Sonal Divekar
Sonal Divekar is an analyst on DRG’s Infectious, Niche & Rare Diseases team, covering diverse indications across the niche & rare portfolio. Prior to this role, she was working as a Senior Analyst at Merck’s Global Centre for Analytics and Forecasting. Her role focused on creating Long Range Forecasts and Demand Forecasts for therapeutic areas like Diabetes and Immunology for the European market. She holds a Master’s degree in Marketing Management from Symbiosis Institute of Business Management, India and a Master’s degree in Microbiology from Pune University, India.