Parkinson’s disease (PD) is predominantly recognized as a motor disorder, but PD is also associated with a diverse mix of disabling nonmotor symptoms, including cognitive impairment and dementia. PD dementia is progressive and severely impacts QOL and independence, and most expert neurologists interviewed by DRG cite dementia as having the greatest unmet need for new therapeutics among all PD nonmotor symptoms. Available antidementia agents (mostly prescribed off-label) are largely ineffective. Opportunity for premium pricing and limited competition has recently spurred industry activity in this arena and a number of novel agents are in early-phase development. Understanding current management strategies, prevailing market access factors, and the market outlook for PD dementia is crucial for developers advancing new drugs for this understudied and underdeveloped market space.

Questions Answered

  • What are the key areas of unmet need and opportunity in the PD dementia market?
  • What are the key drivers and limiters of the PD dementia market?
  • How does each player influence the market, and how will this change in the future?
  • What is the expected impact of novel therapy launches, and how might they impact opportunities in the PD dementia market?

Geography: United States

Primary research: 6 KOL interviews in Q1 2019

Key companies covered: Adamas, Allergan, Alkahest, Anavex, Eli Lilly, IRLAB

Key drugs covered: Rivastigmine, donepezil, galantamine, memantine, Namzaric, GRF6019/6021, ANAVEX 2-73, LY3154207, IRL752

Table of contents

  • Parkinson's Disease - Executive Insights - Executive Insights (US)
    • Executive Insights - Parkinson's Disease Dementia

Author(s): Bethany Christmann, PhD

Bethany Christmann, Ph.D., has been with DRG since 2015, and is a Senior Business Insights Analyst with the Central Nervous System/Ophthalmology team. In this role, she covers the neurology space, specializing in Parkinson’s disease and epilepsy; she provides expert insight and authors primary market research and forecasting content focused on these and other neurology indications. Prior to joining DRG, Bethany earned her Ph.D. in neuroscience from Brandeis University, where she studied the cellular interactions involved in memory consolidation and their link to sleep behavior.

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