DRG Epidemiology's coverage of myelodysplastic syndromes comprises epidemiological estimates of key patient populations across 45 countries worldwide. We report both the incidence and prevalence of myelodysplastic syndromes for each country, as well as annualized case counts projected to the national population.

Most patient populations are forecast over a period of 20 years for the major mature pharmaceutical markets and 10 years for the other countries covered in this report. In addition to forecasting incident and prevalent patient populations, the number of drug-treatment opportunities at specific lines of therapy are also forecast across the developed world.

DRG Epidemiology's myelodysplastic syndromes forecast will answer the following questions:

  • In developing countries, what impact will economic growth and development have on the number of people diagnosed with myelodysplastic syndromes per year?
  • How will improvements in survival change the number of people living with a diagnosis of myelodysplastic syndromes?
  • Of all people diagnosed with myelodysplastic syndromes, how many in each country across the developed world are drug-treated?
  • How will demographic trends, such as population aging and improving life expectancy, affect the epidemiology of myelodysplastic syndromes over the forecast period?

All forecast data are available on the DRG Insights Platform in tabular format, with options to download to MS Excel. All populations are accompanied by a comprehensive description of the methods and data sources used, with hyperlinks to external sources. A summary evidence table generated as part of our systematic review of the epidemiological literature is also provided for full transparency into research and methods. In addition, we provide a graphical depiction of the patient flow between or within different disease states for the major mature pharmaceutical markets. These patient flow diagrams are provided at the regional level, but may be requested for any specific country or forecast year.

DRG Epidemiology provides at least ten years of forecast data for the following myelodysplastic syndromes patient populations:

  • Diagnosed incident cases by FLT3 status
  • Diagnosed incident cases by histology
  • Diagnosed prevalentcases - MDS by IPSS risk
  • Diagnosed prevalent cases - MDS by IPSS-R risk
  • Diagnosed prevalent cases by histology
  • FLT3 mutated by subtype
  • Drug-treatment subpopulation(s)
  • TP53 mutated by subtype
  • Myelodysplastic syndromes diagnosed incident cases
  • Myelodysplastic syndromes diagnosed prevalent cases

… and more (details available on request).

Note: coverage may vary by country and region.

Table of contents

  • Myelodysplastic Syndromes - Epidemiology - Mature Markets
    • Introduction
      • Key Findings
        • Overview
          • Annual Incidence of Myelodysplastic Syndromes per 100,000 People of All Ages in 2020 and 2040
          • Annual Prevalence of Myelodysplastic Syndromes per 100,000 People of All Ages in 2020 and 2040
          • Relative Sizes of the Factors Contributing to the Trend in Prevalent Cases of Myelodysplastic Syndromes Over the Next 20 Years
          • Analysis of Diagnosed Prevalent Cases of Myelodysplastic Syndromes in the Countries Under Study in 2020 by IPSS-R Score
      • Epidemiology Data
      • Methods
        • Diagnosed Incidence
        • Diagnosed Prevalence
        • Morphologic Subtype
        • IPSS and IPSS-R Score
        • FLT3 Mutation Status
        • AML Transformation Events
        • TP53 Mutation Status
        • Drug-Treated Cases
      • Reference Materials
        • Literature Review
          • Studies Included in the Analysis of MDS
          • Studies Excluded from the Analysis of MDS
        • Risk/Protective Factors
          • Risk/Protective Factors for MDS
        • Bibliography

    Author(s): Ullas Ulahannan; Atul Sharma, M.P.H.

    Ullas Ulahannan, M.P.H., is an associate epidemiologist at DRG, part of Clarivate. Prior to joining DRG, he worked at Jhpiego (a John Hopkins University affiliate) as a senior program officer evaluating, implementing, and monitoring various health programs in collaboration with the state and central governments of India. He earned a B.S. in nursing from Rajiv Gandhi University and an M.P.H. from Manipal University.

    Atul Sharma, M.P.H., is an associate epidemiologist at DRG, part of Clarivate. He holds a master’s degree in public health from the School of Public Health, Post-Graduate Institute of Medical Education and Research, and a bachelor’s degree in dental surgery from MN DAV Dental College and Hospital.


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