DRG Epidemiology’s coverage of hepatocellular carcinoma comprises epidemiological estimates of key patient populations in 45 countries worldwide. We report both the incidence and prevalence of hepatocellular carcinoma for each country, as well as annualized case counts projected to the national population.

Most patient populations are forecast over a period of 20 years for the major mature pharmaceutical markets and 10 years for the other countries covered in this report. In addition to forecasting incident and prevalent patient populations, the number of drug-treatment opportunities at specific lines of therapy are forecast.

DRG Epidemiology’s hepatocellular carcinoma forecast will answer the following questions:

  • How will changes in the levels of exposure to known risk or protective factors affect the number of people diagnosed with hepatocellular carcinoma per year?
  • In developing countries, what impact will economic growth and development have on the number of people diagnosed with hepatocellular carcinoma per year?
  • How will improvements in survival change the number of people living with a diagnosis of hepatocellular carcinoma?
  • How will a declining risk of recurrence change the number of people diagnosed with hepatocellular carcinoma per year?
  • Of all people with hepatocellular carcinoma, how many in each of the major mature pharmaceutical markets have been formally diagnosed?
  • Of all people diagnosed with hepatocellular carcinoma, how many in each of the major mature pharmaceutical markets are drug-treated?

All forecast data are available on the DRG Insights Platform in tabular format, with options to download to MS Excel. All populations are accompanied by a comprehensive description of the methods and data sources used, with hyperlinks to external sources. A summary evidence table generated as part of our systematic review of the epidemiological literature is provided for full transparency into research and methods. In addition, we provide a graph of the patient flow between or within different disease states for the countries considered in this report. These patient flow diagrams are provided at the regional level but may be requested for any specific country or forecast year.

DRG Epidemiology provides at least ten years of forecast data for the following hepatocellular carcinoma patient populations:

  • Diagnosed incident cases of hepatocellular carcinoma.
  • Diagnosed incident cases by stage distribution.
  • Diagnosed prevalent cases of hepatocellular carcinoma.
  • Diagnosed prevalent cases by metastasis status.
  • Advanced first-line drug-treatable hepatocellular carcinoma population.
  • Advanced first-line drug-treatable population by treatment.
  • Advanced second-line drug-treatable hepatocellular carcinoma subpopulation(s).
  • Advanced second-line drug-treatable population by treatment.
  • Intermediate drug-treatable hepatocellular carcinomapopulation.
  • Intermediate drug-treatable population by treatment.
  • Early drug-treatable hepatocellular carcinoma population.
  • Early drug-treatable population by treatment.

… and more (details available on request).

Note: Coverage may vary by country and region.

Table of contents

  • Hepatocellular Carcinoma - Epidemiology - Mature Markets
    • Introduction
      • Diagnosed Incidence of Hepatocellular Carcinoma per 100,000 per Year Among People of All Ages in 2017 and 2037
      • Patient Flow in Hepatocellular Carcinoma Across All Countries Under Study in 2017
      • Relative Sizes of the Factors Contributing to the Trend in Diagnosed Incident Cases of Hepatocellular Carcinoma over the Next 20 Years
      • Analysis of the Diagnosed Incident Cases of Hepatocellular Carcinoma in 2017 by Stage
      • Number of Additional Incident Cases of Hepatocellular Carcinoma Incurred in 2017-2037 in the Countries Under Study
    • Epidemiology Data
    • Methods
      • Lifetime DALYs Gained
      • Diagnosed Incident Cases
      • Stage Distribution of Hepatocellular Carcinoma
      • Recurrent Incident Cases of Hepatocellular Carcinoma
      • Diagnosed Prevalent Cases
      • Drug-Treatable Populations
      • Drug-Treated Populations
    • Reference Materials
      • Literature Review
        • Studies Included in the Analysis of Hepatocellular Carcinoma
        • Studies Excluded from the Analysis of Hepatocellular Carcinoma
      • Risk/Protective Factors
        • Risk/Protective Factors for Hepatocellular Carcinoma
      • Bibliography

    Author(s): Oliver Blandy, M.Sc.

    Oliver Blandy, M.Sc., is a senior epidemiologist at DRG, part of Clarivate. Before joining DRG, Oliver worked as a research assistant for Imperial College London, where he was the lead for several studies within an NIRH-funded research group investigating healthcare-associated infections and antimicrobial resistance. He holds an M.Sc. from the University of Bristol, where he specialized in nutrition, physical activity, and public health. He also holds a B.Sc. in chemistry and a postgraduate certificate in education, both from the University of Bristol.


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