DRG Epidemiology’s coverage of hepatitis B virus (HBV) infection comprises epidemiological estimates of key patient populations across 45 countries. We report the total prevalence of HBV infection for each country, as well as annualized case counts projected to the national population.

The patient populations are forecast over a period of ten years for all the countries covered in this report.

All forecast data are available on the DRG Insights Platform in tabular format, with options to download to MS Excel. All populations are accompanied by a comprehensive description of the methods and data sources used, with hyperlinks to external sources. A summary evidence table generated as part of our systematic review of the epidemiological literature is also provided for full transparency into research and methods.

DRG Epidemiology's HBV infection forecast will answer the following questions:

  • How will changes in HBV vaccine coverage impact the prevalence of HBV infections?
  • Of all the people diagnosed with HBV infection, what percentage in each country across the major markets are drug-treated?
  • How will demographic trends, such as population aging and improving life expectancy, affect the epidemiology of HBV infection over the forecast period?

Table of contents

  • Hepatitis B Virus - Epidemiology - Americas Data
    • Introduction
      • Trends in the Growth of Total Prevalent Cases of HBV Infection Over the Next Ten Years
      • Relative Sizes of the Contributing Factors to the Trend in Prevalent Cases of HBV Infection Over the Next Ten Years
      • Number of Prevalent Cases of HBV Infection Avoided Over the Period 2019-2029 Across the Countries in This Region
    • Epidemiology Data
    • Methods
      • Total Prevalence
      • HBeAg Status
      • Diagnosed Prevalence
      • Percentage Drug-Treated
    • Reference Materials
      • Literature Review
        • Studies Included in the Analysis of HBV Infection
        • Studies Excluded from the Analysis of HBV Infection
      • Risk/Protective Factors
        • Risk/Protective Factors for HBV Infection
      • Bibliography

Author(s): Alison Isherwood, MSc, MRes, PhD; Mike Hughes, MSc, PhD

Alison Isherwood, B.Sc., M.Res., M.Sc., Ph.D. joined Decision Resources Group in 2008, as an Epidemiologist. Alison holds a B.Sc. in Medical Microbiology, Masters by Research in the Life Sciences and a M.Sc. in Epidemiology all from the University of Edinburgh. Prior to joining Decision Resources Inc., she was working on her Ph.D. in Molecular Virology, specializing on the severe acute respiratory syndrome (SARS) coronavirus, at the University of Reading. In her role at Decision Resources Group, Alison is currently an Epidemiology team lead as well as project managing custom epidemiology work in multiple therapy areas. Alison’s area of specialization at DRG is cancer, particularly breast cancer.

Mike joined Decision Resources as an epidemiologist in 2006. He has many years’ experience in the mathematical modeling of healthcare service delivery, cardiovascular and cancer epidemiology, biostatistics, meta-analysis and systematic reviewing.

He has been principal author on many published articles in leading international journals in the areas of risk modeling in intensive care and cardiovascular medicine. He has also been responsible for developing national guidelines on behalf of NICE and the American College of Chest Physicians for the treatment of atrial fibrillation, stroke and hypertension. He is particularly interested in modeling patient flows in cancer and methods for forecasting disease burden in non-communicable epidemiology.

Dr. Hughes received his Ph.D. in risk modeling in intensive care in 2003 from City University, London and is currently enrolled in a Ph.D. program in statistical causation and foundations of probability theory at the University of Nottingham.


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