With its launch in August 2016, Zinbryta became the 14th disease-modifying therapy (DMT) approved to treat relapsing forms of multiple sclerosis (MS) in the United States. The monoclonal antibody boasts solid efficacy, infrequent dosing, and a novel anti-inflammatory mechanism of action, but the potential for serious long-term side effects has led to a restrictive U.S. label. DRG’s launch-tracking series will examine how the perception and performance of Zinbryta evolves through one year postlaunch in an MS market that, on the one hand, is increasingly transformed by a growing array of DMTs with compelling risk-benefit profiles, but on the other hand, can and will support a clinical role for each new agent in treating a heterogeneous disease with a complex natural history.

What you will learn in this content:

  • What is U.S. neurologists’ awareness of and familiarity with Zinbryta, and what are their perceptions of the product?
  • Among prescribers, for which patients are they prescribing Zinbryta, what are the reasons for prescribing, and how satisfied are they with Zinbryta?
  • What are the promotional messages and activities that Biogen/AbbVie are employing in support of the Zinbryta launch?
  • How do prescribers and nonprescribers compare across key metrics?
  • How is the trial and adoption of Zinbryta tracking compared with other product launches in the MS market?

Methodology: ~75-100 U.S. neurologists complete a 30-minute online quantitative survey with several open-ended questions for qualitative feedback. In addition, ten surveyed specialists participate in a 30-minute follow-up qualitative interview.

Key drugs: Zinbryta, Lemtrada, Tysabri, Ocrevus, Gilenya, Tecfidera, Copaxone, beta-interferons

Key companies: Biogen, AbbVie, Sanofi Genzyme, Novartis, Teva, Roche/Genentech

Related reports: Emerging Therapies Zinbryta Wave 1, Emerging Therapies Lemtrada Waves 1-4

Table of contents

  • Multiple Sclerosis - Emerging Therapies - Zinbryta Launch Tracking Wave 2 (US)

Author(s): Jonathan Searles

Jonathan W. Searles is a Senior Director in the CNS/Ophthalmology unit at DRG, overseeing the neurology research stream. Prior to joining DRG, Mr. Searles received a B.A. degree, summa cum laude, from Brandeis University; during this time, Mr. Searles conducted research projects at the Harvard University Peabody Museum and at Brandeis.


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