The wet age-related macular degeneration (AMD) therapy market has long been dominated by three VEGF inhibitors—Roche / Genentech / Chugai’s Avastin, Roche / Genentech / Novartis’s Lucentis, and Regeneron / Bayer HealthCare / Santen’s Eylea—but competition has intensified with the U.S. approval of Novartis’s Beovu in late 2019. We expect this launch to be followed by other late-phase therapies, and biosimilars are on the horizon; thus, Eylea's and Lucentis’s positions will be increasingly threatened as the market becomes more fragmented. In contrast to the treatment of wet AMD, management of patients with dry AMD is limited to minimally effective vitamin formulations because no prescription therapies are approved for this large and underserved subpopulation. However, several novel therapies are advancing in the pipeline for dry AMD, increasing the possibility that an effective therapy may soon emerge.

Questions Answered:

  • Do KOLs perceive any differences between Avastin, Eylea, Lucentis, and Beovu? How is the wet AMD treatment algorithm expected to change, if at all, as new products launch?
  • Biosimilar versions of Eylea and Lucentis are forecast to launch within the next five years. What is the likely impact of these therapies on current and emerging VEGF inhibitors?
  • A substantial unmet need in wet AMD exists for therapies with longer dosing intervals than those offered by current therapies. To what extent are late-phase therapies such as Roche’s ranibizumab port delivery system and faricimab expected to capitalize on this unmet need?
  • With the anticipated approval of Apellis’s pegcetacoplan as the first drug for GA, how likely is it to be incorporated into clinical practice?

Product Description:

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Markets covered: United States, France, Germany, Italy, Spain, United Kingdom, and Japan.

Primary research: ~20 country-specific interviews with thought-leading retinal specialists. Supported by survey data collected for this and other DRG research.

Epidemiology: Total prevalence of late AMD by country, segmented by GA and wet AMD subpopulations, including diagnosed and drug-treated rates.

Forecast: Ten-year, annualized, drug-level sales and patient share of key GA and wet AMD therapies through 2029, segmented by brands / biosimilars and epidemiological subpopulations.

Emerging therapies: Phase III / PR: 10 drugs; Phase II: 15 drugs; coverage of select Phase I products.

Table of contents

  • Dry And Wet Age-Related Macular Degeneration - Landscape & Forecast - Disease Landscape & Forecast

Author(s): Thomas Cronin; Deepti Sharma, MPH; Emma McFadden, PhD; Natalie Taylor, PhD

Since joining DRG in late 2019, Tom has worked on reports focusing on psychiatric and ophthalmologic disorders for the CNS team. His background is in biochemistry and he previously worked in the intellectual property field as a registered Patent Agent. Prior to joining DRG, Tom was an Intellectual Property Manager in a Boston-based biopharmaceutical company focusing on treating metabolic diseases and disorders. He has also worked for several internationally recognized law firms representing corporate and institutional clients in all matters of life science – related intellectual property.

Deepti started working with Decision Resources Group as an intern in early 2017 and currently works as an associate epidemiologist.She works with a team of global epidemiologists in providing robust forecast estimates for multiple indications.

Deepti holds a Master’s in Public Health degree from PGIMER School of Public Health, and a bachelor’s degree in dental surgery from HP Government Dental College from Himachal Pradesh University, India.

 

Emma McFadden, Ph.D., is a Director within the Central Nervous System/Ophthalmology disorders group. Her main focus is on ophthalmic indications, such as age-related macular degeneration, diabetic retinopathy, and diabetic macular edema, although she has authored research across a number of other indications, including multiple sclerosis and epilepsy. 

Prior to joining Decision Resources Group, Emma earned a B.A. in neuroscience and a Ph.D. in biochemistry from Trinity College Dublin.

 

Natalie Taylor, Ph.D. is a Principal Business Insights Analyst with the central nervous system/ophthalmology disorders team at Decision Resources Group. She has over ten years of experience authoring primary and market research reports for pharmaceutical industry clients across multiple psychiatry, pain, neurology, and ophthalmology therapy areas.

Prior to joining DRG, Dr. Taylor worked at QuintilesIMS as manager of the central nervous system portfolio of Disease Insights market forecasting offerings. She completed her Ph.D. in Physiology at Dartmouth College in Hanover, New Hampshire, where she studied the role of serotonergic neurons in the medullary raphe on modulating respiratory responses in mammals. She holds a B.S. in Biology from Dickinson College in Carlisle, Pennsylvania.


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