Treatment for recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) has remained relatively unchanged in the past ten years, and Erbitux-based regimens continue to be the mainstay of treatment. However, immune checkpoint inhibitors are revolutionizing the treatment algorithm for this patient population with the 2016/2018 approvals of Merck & Co.’s Keytruda and Bristol-Myers Squibb / Ono Pharmaceutical’s Opdivo for previously treated recurrent or metastatic SCCHN and the 2019 approval of Merck & Co.’s Keytruda for the first-line recurrent or metastatic setting. Although SCCHN has historically proved to be a complex challenge for drug developers, many immune-oncology approaches and other drug classes are competing in late-phase development for SCCHN, both in the metastatic setting and in earlier stages of the disease. Several agents are being positioned for the untapped and lucrative locoregionally advanced SCCHN setting and are also poised to contribute to the robust market growth over the 2019-2029 forecast period.
- How large are the clinically and commercially relevant drug-treatable SCCHN populations, and how will drug-treatment rates change over time?
- What is the current state of treatment for recurrent or metastatic SCCHN? What are interviewed experts’ views on these therapies?
- Which pipeline products are poised to become options for the treatment of SCCHN, and what sales / uptake could they secure?
- What are the key drivers and constraints in the SCCHN market, and how will the major markets evolve over the ten-year forecast period?
Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.
- Squamous Cell Carcinoma Of The Head And Neck - Landscape & Forecast - Disease Landscape & Forecast
Author(s): Carolina do Pazo, M.Sc; Atul Sharma, MPH
Carolina do Pazo, M.Sc., is a Business Insights Analyst in the oncology division at Decision Resources Group. Prior to joining DRG, she completed a MSc in Biotechnology, Bioprocessing and Business Management with distinction at the University of Warwick, as a Chevening scholar. She also earned her first-class BSc and BEng in Biotechnology from the Universidad ORT. Ms. do Pazo has worked as a Research Scientist at the Institut Pasteur de Montevideo, analysing the ageing process of yeast cells, and has been part of a project between Indiana University and Universidad ORT that analysed the production of nanohybrids for drug delivery systems applications.
Atul Sharma started working in Decision Resources Group as an intern in early 2016 and currently works as an associate epidemiologist. He performs fully documented systematic reviews of both published and grey literature on the epidemiology of assigned diseases and their risk factors to estimate incidence/prevalence over a 10-30 year period. He produces analyses for pharmaceutical drug developers on the descriptive epidemiology of major drug indications in mature and developing markets.
He holds a Master’s in Public Health degree from School of Public Health, Post-Graduate Institute of Medical Education and Research and a Bachelor’s in dental surgery from MN DAV Dental College & Hospital.