The introduction of immune checkpoint inhibitor therapies, Keytruda (Merck & Co.) and Opdivo ± Yervoy (Bristol Myers Squibb), as well as BRAF/MEK inhibitor combination regimens, such as Roche / Genentech’s Zelboraf + Cotellic, Novartis’s Tafinlar + Mekinist, and, more recently, Pfizer / Array BioPharma’s Braftovi + Mektovi, has significantly changed the treatment landscape for malignant melanoma in both the resectable and metastatic settings. Nonetheless, opportunities remain for novel agents specifically targeting the underpenetrated BRAF wild-type unresectable or metastatic population. With the expected introduction of novel agents and combination regimens, the malignant melanoma treatment algorithm will continue to evolve. In such a dynamic indication, marketed drugs need to be carefully positioned to achieve optimal uptake.

Questions Answered:

  • How large are the clinically and commercially relevant malignant melanoma drug-treatable populations? Will drug-treatment rates increase over the forecast period?
  • What is the current treatment landscape in malignant melanoma? Which currently approved drugs are the most important and why?
  • Which drugs in late-phase development are poised to change the treatment landscape for malignant melanoma and how? What sales/uptake could these drugs secure in the malignant melanoma market?
  • What are the key drivers and constraints in the malignant melanoma market, and how will the market evolve over the forecast period?

Content Highlights

Geographies: United States, EU5, Japan.

Primary research: 20 country-specific interviews with thought-leading medical oncologists, supported by survey data collected for this and other DRG research.

Epidemiology: Diagnosed incidence of malignant melanoma by country, segmented by disease stage and BRAF mutation status.

Forecast: 10-year, annualized, drug-level sales and patient share of key malignant melanoma therapies through 2029, segmented by brands/generics and epidemiological subpopulations.

Emerging therapies: Phase III: 9 drugs; Phase II: 11 drugs; coverage of select preclinical and Phase I products.

Product Description

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Table of contents

  • Malignant Melanoma - Landscape & Forecast - Disease Landscape & Forecast

Author(s): Liseth Parra; Surup Dey

Liseth M Parra, Ph.D., is an analyst on the Oncology team at Decision Resources Group with an extensive background in oncology research and market analysis. Prior to joining DRG, Liseth generated valuable offerings and comprehensive strategic solutions for leading R&D clinical, commercial, and marketing teams in oncology as a research analyst for Kantar Health and as an independent consultant. Liseth holds a Ph.D. in neurobiology from the University of California, San Diego and completed a postdoctoral fellowship in oncology at the Brigham and Women’s Hospital, Harvard Medical School. Liseth supports DRG’s syndicated oncology research offerings, focusing on malignant melanoma disease landscape and forecast analysis.

Surup Dey has a background in medical laboratory science from Christian Medical College, Vellore with a postgraduate degree in Public Health specializing in Epidemiology from Manipal University. He has expertise in Real World Data analysis and in conducting fully documented systematic reviews on the epidemiology of various diseases and develop forecast models.

Prior to joining DRG, he worked for 2 years in the field of medical diagnostic microbiology and was also involved in the diagnosis of rare hematological disorders. He was involved in epidemiological and operational research related to tuberculosis and health system as well as conducted situational assessment of HIV counselling and testing services in the private health facilities in the four districts of West Bengal, India.


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