Renal anemia is a common complication of chronic kidney disease (CKD). Although there are treatments for the disease, physicians, patients, and healthcare systems have concerns about their limitations. Delivery, safety issues, and tightening healthcare budgets have resulted in increased scrutiny of the effectiveness and tolerability of such therapies as intravenous (IV) iron and erythropoiesis-stimulating agents (ESAs). The renal anemia therapy market will expand over the 2019-2029 study period, fueled by increasing prevalence and demand for new drugs that can effectively, safely, and conveniently control the disease. The launches of several hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors are expected during the study period; of this drug class, roxadustat was the first to launch (in Japan in 2019). Although these new therapies offer advantages over current therapies, they will face major challenges, including reimbursement hurdles and an increasingly stringent regulatory environment.

QUESTIONS ANSWERED

  • What opportunities exist for the marketers of the emerging oral HIF-PH inhibitors to promote their noninvasive route of administration, particularly for patients not on dialysis?
  • Will establishing cardiovascular (CV) safety be key for the market uptake of HIF-PH inhibitors given the CV issues associated with current therapies?
  • With the availability of biosimilars in the United States, will emerging therapies offering only incremental improvements over existing therapies struggle?

PRODUCT DESCRIPTION

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Table of contents

  • Renal Anemia - Landscape & Forecast - Disease Landscape & Forecast
    • COVID-19
      • Key Findings
        • Renal Anemia Key Findings - December 2020
      • Key Updates
        • January 2021
        • November 2020
        • July 2020
        • May 2020
        • March 2020
      • Market Outlook
        • Key Findings
          • Market Share of Drug Classes for Renal Anemia, Dialysis: 2019
          • Market Share of Drug Classes for Renal Anemia, Nondialysis: 2019
          • Market Share of Drug Classes for Renal Anemia, Dialysis: 2029
          • Market Share of Drug Classes for Renal Anemia, Nondialysis: 2029
          • Renal Anemia SWOT Analysis
        • COVID-19 Areas of Potential Forecast Impact
          • COVID-19: Areas of Potential Forecast Impact
        • Market Drivers and Constraints
          • What Factors Are Driving the Market for Renal Anemia?
          • What Factors Are Constraining the Market for Renal Anemia?
          • Key Market Events for Renal Anemia: 2019-2029
        • Drug-Class-Specific Trends
          • Annual Sales of Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors in Renal Anemia, Dialysis, in the Major Markets: 2019-2029
          • Annual Sales of Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors in Renal Anemia, Nondialysis, in the Major Markets: 2019-2029
          • Patient Share of Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors in Renal Anemia, Dialysis, in the Major Markets: 2019-2029
          • Patient Share of Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors in Renal Anemia, Nondialysis, in the Major Markets: 2019-2029
          • Annual Sales of Erythropoietin-Stimulating Agents in Renal Anemia, Dialysis, in the Major Markets: 2019-2029
          • Annual Sales of Erythropoietin-Stimulating Agents in Renal Anemia, Nondialysis, in the Major Markets: 2019-2029
          • Patient Share of Select Erythropoietin-Stimulating Agents in Renal Anemia, Dialysis, in the Major Markets: 2019-2029
          • Patient Share of Select Erythropoietin-Stimulating Agents in Renal Anemia, Nondialysis, in the Major Markets: 2019-2029
      • Forecast
        • Market Forecast Assumptions – Renal Anemia Nondialysis
        • Market Forecast Assumptions – Renal Anemia Dialysis
        • Market Forecast Dashboard - Renal Anemia Nondialysis
        • Market Forecast Dashboard - Renal Anemia Dialysis
      • Etiology and Pathophysiology
        • Disease Overview
        • Select Diagnostic Criteria for Renal Anemia
        • Etiology
          • Factors Contributing to Renal Anemia
        • Pathophysiology
          • Pathophysiological Mechanism in Renal Anemia
        • Disease Progression
          • Classification of Chronic Kidney Disease by Severity
        • Key Pathways and Drug Targets
          • Drug Targets
      • Epidemiology
        • Key Findings
          • Epidemiology Populations
            • Disease Definition
            • Methods
            • Sources Used for Prevalence of Renal Anemia
            • Total Prevalent Cases of Renal Anemia (thousands): 2019-2029
            • Disease Definition
            • Methods
            • Sources Used for Prevalent Cases of Renal Anemia by Dialysis
            • Total Prevalent Cases of Renal Anemia by Dialysis Status (thousands): 2019-2029
            • Diagnosed Prevalent Cases of Renal Anemia in Dialysis (thousands): 2019-2029
            • Diagnosed Prevalent Cases of Renal Anemia in Chronic Kidney Disease Nondialysis (thousands): 2019-2029
            • Drug-Treated Prevalent Cases of Renal Anemia in Dialysis (thousands): 2019-2029
            • Drug-Treated Prevalent Cases of Renal Anemia in Chronic Kidney Disease Nondialysis (thousands): 2019-2029
        • Current Treatment
          • Key Findings
            • Treatment Goals
              • Key Endpoints Used in Clinical Trials for Renal Anemia
              • Hemoglobin Targets: Select Renal Anemia Guidelines
            • Key Current Therapies
              • Overview
              • Mechanism of Action of Key Current Drug Classes Used for Renal Anemia
              • Current Treatments Used for Renal Anemia
              • Market Events Impacting the Use of Key Current Therapies in Renal Anemia
              • Advantages and Disadvantages of Epoetin Alfa
              • Expert Insight: Epoetin Alfa
              • Advantages and Disadvantages of Epoetin Beta
              • Expert Insight: Epoetin Beta
              • Advantages and Disadvantages of Epoetin Theta
              • Advantages and Disadvantages of Darbepoetin Alfa
              • Expert Insight: Darbepoetin Alfa
              • Advantages and Disadvantages of Methoxy Polyethylene Glycol-Epoetin Beta
              • Expert Insight: Methoxy Polyethylene Glycol-Epoetin Beta
              • Advantages and Disadvantages of Ferric Citrate
              • Expert Insight: Ferric Citrate
              • Advantages and Disadvantages of Iron Supplements
              • Expert Insight: Iron Supplements
            • Medical Practice
              • Overview
              • Country-Specific Renal Anemia Treatment Guidelines
              • Factors Influencing Drug Selection in Renal Anemia
              • Treatment Decision Tree for Renal Anemia: United States
              • Treatment Decision Tree for Renal Anemia: Europe
              • Treatment Decision Tree for Renal Anemia: Japan
          • Unmet Need Overview
            • Current and Future Attainment of Unmet Needs in Renal Anemia
            • Top Unmet Needs in Renal Anemia: Current and Future Attainment
          • Emerging Therapies
            • Key Findings
              • Pipeline Trends in Renal Anemia
            • Key Emerging Therapies
              • Key Therapies in Development for Renal Anemia
              • Estimated Launch Dates of Key Emerging Therapies for the Treatment of Renal Anemia
              • Roxadustat Profile
              • Analysis of the Clinical Development Program for Roxadustat
              • Expert Insight: Roxadustat
              • Expectations for Launch and Sales Opportunity of Roxadustat in Renal Anemia
              • Key Development Milestones for Roxadustat in the Treatment of Renal Anemia
              • Vadadustat Profile
              • Analysis of the Clinical Development Program for Vadadustat
              • Expert Insight: Vadadustat
              • Expectations for Launch and Sales Opportunity of Vadadustat in Renal Anemia
              • Key Development Milestones for Vadadustat in the Treatment of Renal Anemia
              • Daprodustat Profile
              • Analysis of the Clinical Development Program for Daprodustat
              • Expert Insight: Daprodustat
              • Expectations for Launch and Sales Opportunity of Daprodustat in Renal Anemia
              • Key Development Milestones for Daprodustat in the Treatment of Renal Anemia
              • Molidustat Profile
              • Analysis of the Clinical Development Program for Molidustat
              • Expert Insight: Molidustat
              • Expectations for Launch and Sales Opportunity of Molidustat in Renal Anemia
              • Key Development Milestones for Molidustat in the Treatment of Renal Anemia
              • Enarodustat Profile
              • Analysis of the Clinical Development Program for Enarodustat
              • Expert Insight: Enarodustat
              • Expectations for Launch and Sales Opportunity of Enarodustat in Renal Anemia
              • Key Development Milestones for Enarodustat in the Treatment of Renal Anemia
            • Early-Phase Pipeline Analysis
              • Select Phase I and Preclinical Development Programs for Renal Anemia
          • Access & Reimbursement Overview
            • Region-Specific Reimbursement Practices
              • Key Market Access Considerations in Renal Anemia: United States
              • General Reimbursement Environment: United States
              • Key Market Access Considerations in Renal Anemia: EU5
              • General Reimbursement Environment: EU5
              • Key Market Access Considerations in Renal Anemia: Japan
              • General Reimbursement Environment: Japan
          • Appendix
            • Key Abbreviations Related to Renal Anemia
            • Brands, Marketers, and Generic Availability of Key Therapies for Renal Anemia: by Market
            • Renal Anemia Bibliography

        Author(s): Tej Pal, M.Pharm.

        Tej Pal, M.Pharm., is an analyst on the Cardiovascular, Metabolic, Renal, and Hematologic Diseases team at DRG, part of Clarivate. Prior to joining DRG, he was an analyst at IQVIA and at Smart Analyst Inc., where he worked closely with top pharmaceutical companies on commercial and technical ad-hoc requests. During his tenure there, he delivered competitive landscape and market insight projects on various oncology indications. He holds a master’s degree in pharmacy with a specialization in pharmaceutical chemistry from the Delhi Institute of Pharmaceutical Sciences and Research in New Delhi, India.


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