The psoriasis therapy market is becoming increasingly lucrative owing to the growing number of approved biologics. Although TNF-alpha inhibitors continue to dominate the market, their premier position is being challenged by the IL-17 inhibitors secukinumab (Novartis’s Cosentyx), ixekizumab (Eli Lilly’s Taltz), and brodalumab (Bausch Health’s Siliq, Leo Pharma’s Kyntheum, Kyowa Hakko Kirin’s Lumicef) and by the IL-12/23 inhibitor ustekinumab (Janssen’s Stelara). With the approvals of the IL-23 inhibitors guselkumab (Janssen’s Tremfya), tildrakizumab (Merck & Co. / Almirall / Sun Pharma’s Ilumya / Ilumetri), and, more recently, risankizumab (AbbVie / Boehringer Ingelheim’s Skyrizi), another effective drug class has been introduced to this competitive market. The landscape for the established biologics will change even further with the increasing availability and use of biosimilars.

Questions answered:

  • How do interviewed KOLs view the efficacy and safety of the IL-17 inhibitors Cosentyx, Taltz, and Siliq / Kyntheum / Lumicef and the emerging IL-17 A/F dual inhibitor, UCB’s bimekizumab, and where are / will these agents be positioned in the psoriasis treatment algorithm?
  • What will be the impact of the IL-23 inhibitors Tremfya, Ilumya, Skyrizi, and Eli Lilly's emerging therapy mirikizumab, and how will they fare in the competitive psoriasis market?
  • How is the oral agent apremilast (Amgen’s Otezla) used to treat psoriasis, and how will it  compare to BMS's emerging oral TYK2 inhibitor, BMS-986165?
  • How fast will uptake of biosimilars occur in psoriasis, and which brands will see the most erosion in patient share and sales?

Geographies: United States, France, Germany, Italy, Spain, United Kingdom, and Japan.

Primary research: 24 country-specific interviews with thought leaders. Supported by survey data collected for this and other DRG research.

Epidemiology: Total diagnosed prevalence of psoriasis by country, segmented by mild and moderate to severe subpopulations.

Emerging therapies: Phase III/PR: 7 drugs; Phase II: 9 drugs; coverage of select preclinical and Phase I products.

Forecast: 10-year, annualized, drug-level sales and patient share of key psoriasis therapies through 2029, segmented by brands/generics and epidemiological subpopulations.

Product Description:

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Table of contents

  • Psoriasis - Landscape & Forecast - Disease Landscape & Forecast
    • Key Updates
      • Q1 2021
        • March 2021
        • February 2021
        • January 2021
      • Q4 2020
        • November 2020
      • Q3 2020
        • July 2020
      • Q2 2020
        • April 2020
    • Key Findings
      • Market Outlook
        • Key Findings
          • Market Share of Psoriasis Drug Classes in 2019
          • Market Share of Psoriasis Drug Classes in 2029
          • Psoriasis SWOT Analysis
        • COVID-19: Areas of Potential Forecast Impact
          • Market Drivers and Constraints
            • What Factors Are Constraining the Market for Psoriasis?
            • Major-Market Sales of Select Drug Classes in Psoriasis: 2019-2029
            • Annual Sales of Biologics and Key Oral Agents in Psoriasis: 2019-2029
          • Drug-Class-Specific Trends
            • Patient Share of TNF-Alpha Inhibitors in Moderate to Severe Psoriasis by Country: 2019-2029
            • Brand and Biosimilar Patient Share for TNF-Alpha Inhibitors in Psoriasis: 2019-2029
            • Major-Market Sales of TNF-Alpha Inhibitors and IL-12/23 Inhibitors in Moderate to Severe Psoriasis: 2019-2029
            • Major-Market Patient Share of TNF-Alpha Inhibitors, IL-12/23 Inhibitors, and IL-17 Inhibitors in Moderate to Severe Psoriasis: 2019-2029
            • Major-Market Patient Share of TNF-Alpha Inhibitors, IL-12/23 Inhibitors, IL-17 Inhibitors, and IL-23 Inhibitors in Moderate to Severe Psoriasis: 2019-2029
            • TYK2 Inhibitors
            • Major-Market Sales of Biologics and Novel Oral Therapies in Moderate to Severe Psoriasis: 2019-2029
            • Major-Market Patient Share of Traditional Oral Drug Classes, PDE-4 Inhibitors, A3 Adenosine Receptor Agonists, and TYK2 Inhibitors in Moderate to Severe Psoriasis: 2019-2029
            • Major-Market Sales of Traditional Oral Drug Classes, PDE4 Inhibitors, A3 Adenosine Receptor Agonists, and TYK2 Inhibitors in Moderate to Severe Psoriasis: 2019-2029
        • Forecast
          • Market Forecast Assumptions
          • Market Forecast Dashboard
        • Etiology and Pathophysiology
          • Etiology
            • Risk Factors
          • Pathophysiology
            • Clinical Features
            • Typical Locations of Psoriasis Lesions
            • Classification of Psoriasis Vulgaris by Phenotype
            • Clinical Forms of Psoriasis
          • Key Pathways and Drug Targets
            • Pathogenesis of Psoriasis and Therapeutic Targets
            • Pathogenesis and Drug Targets
        • Epidemiology
          • Key Findings
            • Epidemiology Populations
              • Disease Definition
              • Methods
              • Sources Used for Diagnosed Symptomatic Prevalence of Psoriasis
              • Number of Diagnosed Symptomatic Prevalent Cases of Psoriasis in the Major Pharmaceutical Markets: 2019-2029 (thousands)
              • Disease Definition
              • Methods
              • Sources Used for Diagnosed Symptomatic Prevalent Psoriasis by Severity
              • Sources Used for Drug-Treated Cases of Psoriasis
              • Number of Diagnosed and Drug-Treated Prevalent Cases of Mild Psoriasis in the Major Pharmaceutical Markets: 2019-2029 (thousands)
              • Number of Diagnosed and Drug-Treated Prevalent Cases of Moderate to Severe Psoriasis in the Major Pharmaceutical Markets: 2019-2029 (thousands)
          • Current Treatment
            • Key Findings
              • Treatment Goals
                • Key Endpoints Used in Clinical Trials for Psoriasis
                • Key Physician Insights on Clinical Endpoints
              • Key Current Therapies
                • Overview
                • Mechanism of Action of Key Current Drug Classes Used for Psoriasis
                • Current Therapies Used for Mild Psoriasis
                • Current Therapies Used for Moderate to Severe Psoriasis
                • Market Events Impacting the Use of Key Current Therapies in Psoriasis
                • Advantages and Disadvantages of Etanercept
                • Expert Insight: Etanercept
                • Advantages and Disadvantages of Infliximab
                • Expert Insight: Infliximab
                • Advantages and Disadvantages of Adalimumab
                • Expert Insight: Adalimumab
                • Certolizumab Pegol
                • Advantages and Disadvantages of Certolizumab Pegol
                • Expert Insight: Certolizumab Pegol
                • Advantages and Disadvantages of Ustekinumab
                • Expert Insight: Ustekinumab
                • Advantages and Disadvantages of Secukinumab
                • Expert Insight: Secukinumab
                • Ongoing Clinical Development of Cosentyx
                • Key Ongoing Clinical Trials of Cosentyx in the Treatment of New-Onset Moderate to Severe Psoriasis
                • Advantages and Disadvantages of Ixekizumab
                • Expert Insight: Ixekizumab
                • Advantages and Disadvantages of Brodalumab
                • Expert Insight: Brodalumab
                • Advantages and Disadvantages of Guselkumab
                • Expert Insight: Guselkumab
                • Advantages and Disadvantages of Tildrakizumab
                • Expert Insight: Tildrakizumab
                • Advantages and Disadvantages of Risankizumab
                • Expert Insight: Risankizumab
                • Advantages and Disadvantages of Apremilast
                • Expert Insight: Apremilast
                • Advantages and Disadvantages of Conventional Systemic Therapies
                • Expert Insight: Conventional Systemic Therapies
                • Advantages and Disadvantages of Topical Therapies
                • Expert Insight: Topical Therapies
              • Medical Practice
                • Overview
                • Treatment Guidelines
                • Psoriasis Treatment Guidelines by Market
                • Drug Selection
                • Factors Influencing Drug Selection in Moderate to Severe Psoriasis
                • Preferred Treatment of Psoriasis by Disease Location and Comorbidities
                • Region-Specific Treatment Practices
                • Treatment Decision Tree for Psoriasis: United States
                • Treatment Decision Tree for Psoriasis: France
                • Treatment Decision Tree for Psoriasis: Germany
                • Treatment Decision Tree for Psoriasis: Italy
                • Treatment Decision Tree for Psoriasis: Spain
                • Treatment Decision Tree for Psoriasis: United Kingdom
                • Treatment Decision Tree for Psoriasis: Japan
            • Unmet Need Overview
              • Current and Future Attainment of Unmet Needs in Psoriasis
              • Top Unmet Needs in Psoriasis: Current and Future Attainment
              • Expert Insight: Unmet Needs in Moderate to Severe Psoriasis
            • Emerging Therapies
              • Key Findings
                • Pipeline Trends in Psoriasis
              • Key Emerging Therapies
                • Therapies in Late-Phase Development for Psoriasis
                • Estimated Launch Dates of Key Emerging Therapies for the Treatment of Psoriasis
                • Mirikizumab
                • Mirikizumab Profile
                • Key Ongoing Clinical Trials of Mirikizumab in the Treatment of Psoriasis
                • Analysis of the Clinical Development Program for Mirikizumab
                • Expert Insight: Mirikizumab
                • Expectations for Launch and Sales Opportunity of Mirikizumab in Psoriasis
                • Likely Uses of Mirikizumab in the Treatment of Psoriasis
                • Bimekizumab Profile
                • Key Ongoing Clinical Trials of Bimekizumab in the Treatment of Psoriasis
                • Analysis of the Clinical Development Program for Bimekizumab
                • Expert Insight: Bimekizumab
                • Expectations for Launch and Sales Opportunity of Bimekizumab in Psoriasis
                • Piclidenoson Profile
                • Analysis of the Clinical Development Program for Piclidenoson
                • Expert Insight: Piclidenoson
                • Expectations for Launch and Sales Opportunity of Piclidenoson in Psoriasis
                • Likely Uses of Piclidenoson in the Treatment of Psoriasis
                • BMS-986165 Profile
                • Key Ongoing Clinical Trials of BMS-986165 in the Treatment of Psoriasis
                • Analysis of the Clinical Development Program for BMS-986165
                • Expert Insight: BMS-986165
                • Expectations for Launch and Sales Opportunity of BMS-986165 in Psoriasis
                • Likely Uses of BMS-986165 in the Treatment of Psoriasis
                • Pefcalcitol Profile
                • Analysis of the Clinical Development Program for Pefcalcitol
                • Expectations for Launch and Sales Opportunity of Pefcalcitol in Psoriasis
                • Tapinarof Profile
                • Key Ongoing Clinical Trials of Tapinarof in the Treatment of Psoriasis
                • Analysis of the Clinical Development Program for Tapinarof
                • Expectations for Launch and Sales Opportunity of Tapinarof in Psoriasis
                • Roflumilast Profile
                • Key Ongoing Clinical Trials of Roflumilast in the Treatment of Psoriasis
                • Analysis of the Clinical Development Program for Roflumilast
                • Expert Insight: Roflumilast
                • Expectations for Launch and Sales Opportunity of Roflumilast in Psoriasis
              • Early-Phase Pipeline Analysis
                • Select Compounds in Early-Phase Development for Psoriasis
            • Access & Reimbursement Overview
              • Region-Specific Reimbursement Practices
                • Key Market Access Considerations in Psoriasis: United States
                • General Reimbursement Environment: United States
                • Key Market Access Considerations in Psoriasis: EU5
                • General Reimbursement Environment: EU5
                • Key Market Access Considerations in Psoriasis: Japan
                • General Reimbursement Environment: Japan
              • Looking for More?
            • Appendix
              • Key Abbreviations Related to Psoriasis
              • Brands, Marketers, and Generic Availability of Current Therapies Used for Psoriasis by Market
              • Psoriasis Bibliography

          Author(s): Mohit Nasa, M.B.A.; T.J. Arndt, M.P.H., C.P.H.

          Mohit Nasa, M.B.A., is a principal analyst on the Immune and Inflammatory Disorders team at DRG, part of Clarivate. He has authored content on such indications as systemic lupus erythropoiesis, psoriasis, asthma, and rheumatoid arthritis. Prior to joining DRG, he worked as a senior business analyst at Novartis, where he was responsible for end-to-end market assessment and related projects for Novartis’s asthma brand Xolair. Mr. Nasa holds a bachelor’s degree in pharmacy and an M.B.A. in marketing and CRM from Amity Business School in India.

          Thomas J. Arndt, M.P.H., C.P.H., is an epidemiologist at DRG, part of Clarivate. He earned his master's degree in public health at the University of Florida, where he conducted an internship developing a clinical model for noninvasively screening for nonalcoholic steatohepatitis (NASH). He also holds a B.S. in microbiology and cell science and a B.A. in Spanish, both from the University of Florida. While studying at the University of Florida, Mr. Arndt worked in two physiology-based research labs focusing on maternal and fetal stresses during pregnancy and parturition.

           


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