The chronic obstructive pulmonary disease (COPD) therapy market is continuing its gradual shift away from long-acting beta2 agonist/inhaled corticosteroid fixed-dose combinations (LABA/ICSFDCs) toward LABA/long-acting muscarinic antagonist (LAMA) FDCs and even LABA/LAMA/ICSFDCs, but current and emerging generics will have a significant impact on this trend. Some branded generic and generic LABA/ICSFDCs have already launched in the United States and Europe, and more will reach the market in the near future; because cost remains a significant driver, we expect competition from these generics to affect the uptake of both LABA/LAMA and LABA/LAMA/ICSFDCs. Physicians are eager to have alternative treatments for this chronic disease, and the development of novel drug classes continues.

QUESTIONS ANSWERED

  • How will markets react to the launch / uptake of generic LABA/ICSFDCs and tiotropium? Will there be significant country-to-country differences in the uptake of these generics?
  • Will LABA/LAMAFDCs continue to gain market share, or will generic therapies or branded LABA/LAMA/ICSFDCs threaten these agents?
  • What proportion of patients currently receive a combination of two or more therapies in separate inhalers? How many receive triple therapy, and will these patients be shifted to FDCs?
  • Which emerging therapies have the most potential for uptake? Will nebulized therapies be accepted?

PRODUCT DESCRIPTION

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Table of contents

  • Chronic Obstructive Pulmonary Disease - Landscape & Forecast - Disease Landscape & Forecast
    • Key Updates
      • Q2 2021
        • June 2021
        • May 2021
        • April 2021
      • Q1 2021
        • March 2021
        • February 2021
        • January 2021
      • Q4 2020
        • December 2020
      • Q3 2020
        • September 2020
      • Q2 2020
        • May 2020
      • Q1 2020
        • February 2020
    • Key Findings
      • Market Outlook
        • Key Findings
          • Market Share of COPD Drug Classes: 2019
          • Market Share of COPD Drug Classes: 2029
          • COPD SWOT Analysis
        • COVID-19: Areas of Potential Forecast Impact
          • Market Drivers and Constraints
            • What Factors Are Driving the Market for Chronic Obstructive Pulmonary Disease?
            • What Factors Are Constraining the Market for Chronic Obstructive Pulmonary Disease?
            • Patient Share of Select Drug Classes for Mild to Moderate COPD in the G7: 2019-2029
            • Patient Share of Select Drug Classes for Severe to Very Severe COPD in the G7: 2019-2029
          • Drug-Class-Specific Trends
            • Brand and Generic Patient Share of Tiotropium in COPD: 2019-2029
            • Major-Market Sales of LAMAs in COPD: 2019-2029
            • Brand and Generic Sales of LABA/ICSs in COPD: 2019-2029
            • U.S. Patient Share of LABA/ICS Combinations in COPD: 2019-2029
            • EU5 Patient Share of LABA/ICS Combinations in COPD: 2019-2029
            • Patient Share of LABA/ICS Combinations for COPD in Japan: 2019-2029
            • Major-Market Sales and Patient Share of LABA/LAMA Combinations for COPD: 2019-2029
            • Major-Market Patient Share of LABA/LAMA/ICS FDCs for Mild to Moderate COPD: 2019-2029
            • Major-Market Patient Share of LABA/LAMA/ICS FDCs for Severe to Very Severe COPD: 2019-2029
        • Forecast
          • Market Forecast Assumptions - COPD 2019-2029 - September 2020
            • Brand and Generic Patient Share of Tiotropium in COPD: 2019-2029
            • Major-Market Sales of LAMAs in COPD: 2019-2029
            • Brand and Generic Sales of LABA/ICSs in COPD: 2019-2029
            • U.S. Patient Share of LABA/ICS Combinations in COPD: 2019-2029
            • EU5 Patient Share of LABA/ICS Combinations in COPD: 2019-2029
            • Patient Share of LABA/ICS Combinations for COPD in Japan: 2019-2029
            • Major-Market Sales and Patient Share of LABA/LAMA Combinations for COPD: 2019-2029
            • Major-Market Patient Share of LABA/LAMA/ICS FDCs for Mild to Moderate COPD: 2019-2029
            • Major-Market Patient Share of LABA/LAMA/ICS FDCs for Severe to Very Severe COPD: 2019-2029
          • Market Forecast Dashboard - COPD 2019-2029 - September 2020
            • Brand and Generic Patient Share of Tiotropium in COPD: 2019-2029
            • Major-Market Sales of LAMAs in COPD: 2019-2029
            • Brand and Generic Sales of LABA/ICSs in COPD: 2019-2029
            • U.S. Patient Share of LABA/ICS Combinations in COPD: 2019-2029
            • EU5 Patient Share of LABA/ICS Combinations in COPD: 2019-2029
            • Patient Share of LABA/ICS Combinations for COPD in Japan: 2019-2029
            • Major-Market Sales and Patient Share of LABA/LAMA Combinations for COPD: 2019-2029
            • Major-Market Patient Share of LABA/LAMA/ICS FDCs for Mild to Moderate COPD: 2019-2029
            • Major-Market Patient Share of LABA/LAMA/ICS FDCs for Severe to Very Severe COPD: 2019-2029
        • Etiology and Pathophysiology
          • Disease Overview
            • Etiology
              • Causative Factors for COPD
            • Pathophysiology
              • Mechanisms Contributing to Symptoms and Progression of COPD
              • Lung Anatomy and Pathogenic Processes in COPD
              • Inflammatory Mechanisms of COPD
            • Disease Progression
              • Key Pathways and Drug Targets
                • Potential Biomarkers of COPD
            • Epidemiology
              • Key Findings
                • Epidemiology Populations
                  • Disease Definition
                  • Methods
                  • Sources Used for Total Prevalent Cases of COPD (GOLD-Defined and Spirometry-Negative)
                  • Total Prevalent Cases of COPD (GOLD-Defined and Spirometry-Negative): 2019-2029 (Thousands)
                  • Disease Definition
                  • Methods
                  • Sources Used for Diagnosed Prevalent Cases of COPD
                  • Diagnosed Prevalent Cases of COPD: 2019-2029 (Thousands)
                  • Disease Definition
                  • Methods
                  • Sources Used for COPD Segmented by Severity
                  • Diagnosed Prevalent Cases of Mild to Moderate COPD: 2019-2029 (Thousands)
                  • Diagnosed Prevalent Cases of Severe to Very Severe COPD: 2019-2029 (Thousands)
                  • Number of Drug-Treated Prevalent Cases of Mild to Moderate COPD in the Major Pharmaceutical Markets: 2019-2029 (Thousands)
                  • Number of Drug-Treated Prevalent Cases of Severe to Very Severe COPD in the Major Pharmaceutical Markets: 2019-2029 (Thousands)
                  • Disease Definition
                  • Methods
                  • Sources Used for Acute Exacerbations of COPD
                  • Acute Exacerbations of COPD: 2019-2029
                  • Disease Definition
                  • Methods
                  • Sources Used for Eosinophilic COPD
                  • Prevalent Cases of Eosinophilic COPD: 2019-2029
              • Current Treatment
                • Key Findings
                  • Treatment Goals
                    • Key Endpoints Used in Clinical Trials for COPD
                  • Key Current Therapies
                    • Overview
                    • Mechanism of Action of Key Current Drug Classes Used for COPD
                    • Current Treatments Used for COPD
                    • Market Events Impacting the Use of Key Current Therapies in COPD
                    • Advantages and Disadvantages of Tiotropium
                    • Expert Insight: Tiotropium
                    • Advantages and Disadvantages of Aclidinium
                    • Expert Insight: Aclidinium
                    • Advantages and Disadvantages of Glycopyrronium
                    • Expert Insight: Glycopyrronium
                    • Advantages and Disadvantages of Nebulized Glycopyrronium
                    • Expert Insight: Nebulized Glycopyrronium
                    • Advantages and Disadvantages of Revefenacin
                    • Expert Insight: Revefenacin
                    • Advantages and Disadvantages of Umeclidinium
                    • Expert Insight: Umeclidinium
                    • Advantages and Disadvantages of Indacaterol
                    • Expert Insight: Indacaterol
                    • Advantages and Disadvantages of Olodaterol
                    • Expert Insight: Olodaterol
                    • Advantages and Disadvantages of Indacaterol / Glycopyrronium
                    • Expert Insight: Indacaterol / Glycopyrronium
                    • Advantages and Disadvantages of Vilanterol / Umeclidinium
                    • Expert Insight: Vilanterol / Umeclidinium
                    • Advantages and Disadvantages of Formoterol / Aclidinium
                    • Expert Insight: Formoterol / Aclidinium
                    • Advantages and Disadvantages of Olodaterol / Tiotropium
                    • Expert Insight: Olodaterol / Tiotropium
                    • Advantages and Disadvantages of Formoterol / Glycopyrronium
                    • Expert Insight: Formoterol / Glycopyrronium
                    • Advantages and Disadvantages of Salmeterol / Fluticasone Propionate
                    • Expert Insight: Salmeterol / Fluticasone Propionate
                    • Advantages and Disadvantages of Formoterol / Budesonide
                    • Expert Insight: Formoterol / Budesonide
                    • Advantages and Disadvantages of Vilanterol / Fluticasone Furoate
                    • Expert Insight: Vilanterol / Fluticasone Furoate
                    • Advantages and Disadvantages of Formoterol / Glycopyrronium / Beclomethasone
                    • Expert Insight: Formoterol / Glycopyrronium / Beclomethasone
                    • Advantages and Disadvantages of Vilanterol / Umeclidinium / Fluticasone Furoate
                    • Expert Insight: Vilanterol / Umeclidinium / Fluticasone Furoate
                    • Advantages and Disadvantages of Formoterol / Glycopyrronium / Budesonide
                    • Expert Insight: Formoterol / Glycopyrronium / Budesonide
                    • Advantages and Disadvantages of Roflumilast
                    • Expert Insight: Roflumilast
                    • Advantages and Disadvantages of Short-Acting Bronchodilators
                    • Expert Insight: Short-Acting Bronchodilators
                    • Advantages and Disadvantages of Methylxanthines
                    • Expert Insight: Methylxanthines
                  • Medical Practice
                    • Overview
                    • Factors Influencing Drug Selection in COPD
                    • Inhaler Devices for COPD
                    • Treatment Decision Tree for COPD: United States
                    • Treatment Decision Tree for COPD: Europe
                    • Treatment Decision Tree for COPD: Japan
                • Unmet Need Overview
                  • Current and Future Attainment of Unmet Needs in Chronic Obstructive Pulmonary Disease
                  • Top Unmet Needs in Chronic Obstructive Pulmonary Disease: Current Attainment and Future Attainment
                  • Expert Insight: Unmet Needs in Chronic Obstructive Pulmonary Disease
                • Emerging Therapies
                  • Key Findings
                    • Pipeline Trends in COPD
                  • Key Emerging Therapies
                    • Key Therapies in Development for COPD
                    • Estimated Launch Dates of Key Emerging Therapies for the Treatment of COPD
                    • Dupilumab Profile
                    • Analysis of the Clinical Development Program for Dupilumab
                    • Expert Insight: Dupilumab
                    • Expectations for Launch and Sales Opportunity of Dupilumab in COPD
                    • Benralizumab Profile
                    • Analysis of the Clinical Development Program for Benralizumab
                    • Expert Insight: Benralizumab
                    • Expectations for Launch and Sales Opportunity of Benralizumab in COPD
                    • Mepolizumab Profile
                    • Analysis of the Clinical Development Program for Mepolizumab
                    • Expert Insight: Mepolizumab
                    • Expectations for Launch and Sales Opportunity of Mepolizumab in COPD
                    • Formoterol / Glycopyrronium / Budesonide Profile
                    • Analysis of the Clinical Development Program for Formoterol / Glycopyrronium / Budesonide
                    • Expert Insight: Formoterol / Glycopyrronium / Budesonide
                    • Expectations for Launch and Sales Opportunity of Formoterol / Glycopyrronium / Budesonide in COPD
                    • RPL554 Profile
                    • Analysis of the Clinical Development Program for RPL554
                    • Expert Insight: RPL554
                    • Expectations for Launch and Sales Opportunity of RPL554 in COPD
                  • Early-Phase Pipeline Analysis
                    • Select Compounds in Early-Phase Development for COPD
                • Access & Reimbursement Overview
                  • Region-Specific Reimbursement Practices
                    • Key Market Access Considerations in COPD: United States
                    • General Reimbursement Environment: United States
                    • Key Market Access Considerations in COPD: EU5
                    • General Reimbursement Environment: EU5
                    • Key Market Access Considerations in COPD: Japan
                    • General Reimbursement Environment: Japan
                • Appendix
                  • Key Abbreviations Related to Chronic Obstructive Pulmonary Disease
                  • Brands, Marketers, and Generic Availability of Current Therapies Used for COPD, by Market
                  • COPD Bibliography

              Author(s): Qinghui Yu; Anupama Ashish Joshi

              Stephanie Niquita Phankon, M.B.B.S., M.P.H., is a senior epidemiologist at DRG, part of Clarivate. She trained as a community physician and has supervised and coordinated various governmental and nongovernmental public health projects. She holds an M.P.H. specializing in epidemiology from the Tata Institute of Social Sciences in Mumbai and a medical degree from Hubei University of Chinese Medicine in the People’s Republic of China.


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