Treatments for opioid addiction are categorized as either substitution therapies—the opioid receptor agonists methadone, buprenorphine, and buprenorphine / naloxone combinations—or abstinence therapies—the opioid receptor antagonist naltrexone. Physicians and patients prefer opioid receptor agonists. Indivior’s Suboxone Film has been one of the most widely prescribed opioid receptor agonists in the United States, and with direct generic competition beginning in early 2019, buprenorphine / naloxone sublingual film products will likely remain a treatment mainstay. In general, these treatments are associated with the potential for misuse and diversion, and relapse rates among patients are high. This report explores the current prescribing practices for opioid addiction in the United States, the factors influencing treatment decisions, and the changes in prescribing that are expected to occur in the coming year.
- What are the patient shares of key therapies used to treat opioid addiction, and how do shares differ across lines of therapy?
- What are the drivers and constraints influencing physicians’ opioid addiction treatment decisions? What factors drive switching to and from specific branded agents (e.g., Sublocade [Indivior], Zubsolv [Orexo]) and generic agents (e.g., buprenorphine / naloxone sublingual film)?
- What are physicians’ estimates regarding patient compliance with current opioid addiction therapies?
- How has use of opioid addiction therapies changed in the past year, and what changes do physicians expect in their prescribing of these drugs in one year?
Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that marketers can create specific messaging around these treatment dynamics to more effectively increase or defend their market position.
Markets covered: United States
Primary research: Survey of 102 psychiatrists in the United States.
Key companies: Alkermes, BioDelivery Sciences, Braeburn, Indivior, Orexo
Key drugs: Bunavail, methadone, Probuphine, Sublocade, Suboxone Film, Subutex, Vivitrol, Zubsolv
Key insights provided:
- Factors influencing disease management and treatment decisions.
- Drivers and constraints of treatment selection.
- Physician-reported treatment practices and brand-level patient shares.
- Rationale for changes in treatment approach.
- Physician insight on persistency and compliance.
- Physician-reported recent / anticipated changes in brand usage or treatment approach.
- Opioid Addiction - Current Treatment - Detailed, Expanded Analysis (US)
- Current Treatment Physician Insights Opioid Addiction US June 2020
Author(s): Nakka Meher Baba Kumar
Niyati Khetarpal is an associate analyst on the Central Nervous System, Pain, and Ophthalmology team at ;In this role, she conducts extensive secondary research to analyze and forecast pharmaceutical markets, with specific expertise in patent research. Prior to joining the company, Niyati obtained her doctorate from the International Centre for Genetic Engineering and Biotechnology for her research on Dengue virus vaccines. She received the Fulbright-Nehru doctoral scholarship in 2014 for her research on Dengue and West Nile virus envelope proteins.