With approximately two-thirds of peripheral arterial disease (PAD) patients being asymptomatic, drug treatment for PAD patients focuses largely on the symptomatic patients who have either intermittent claudication (IC) or critical limb ischemia (CLI). The goals of treatment in IC are twofold; the primary goal is to relieve the symptoms of this condition and improve patients’ daily functioning and quality of life, and the second goal is to reduce the risk of atherothrombotic events. Few drugs have been developed specifically for PAD treatment, and the choice of therapies has changed little in recent years. The treatment armamentarium still consists largely of therapies approved for coronary artery disease (CAD). For PAD, treatment typically consists of an antiplatelet agent, a statin, and an ACE inhibitor; vasoactive agents are also used for symptom relief in IC patients. In some cases, injectable prostaglandin analogues are often used as a last resort, or angioplasty or surgery may also be necessary. Using national patient-level claims data, this report analyzes physician adherence to the treatment guidelines by exploring the use of key therapies in the newly diagnosed and recently treated PAD patient populations. With respect to newly diagnosed patients, the report provides a quantitative analysis of treatment patterns and share by line of therapy, as well as progression between lines, duration of treatment on each line, and use of concomitant treatment. For recently treated patients, the report quantifies a drug’s source of business compared with its competitors and details which drugs precede others through an analysis of add-versus-switch patterns. Additional analyses explore persistency and compliance by brand.

Questions Answered in This Report:

  • Newly diagnosed patients: Approximately 28% of PAD patients begin treatment with a key therapy within a year of their initial diagnosis. What percentage of these patients progress to a second- or third-line drug within the first year? Which products capture the most patient share in the first, second, and third lines of treatment? How often is combination therapy used in each line of therapy?

  • Recently treated patients: Statins were the most commonly prescribed agents to recently treated patients. Which specific drugs garner the most patient share for recently treated PAD patients? When do patients progress from one therapy to the next in PAD, and how does this pattern differ among key drugs? Are most recently treated patients with each key brand coming from new (adds/switches) or continuing business?

  • Pathways to key therapies: Longitudinal claims data reveal relatively consistent use patterns of key therapies among recently treated patients; use of antiplatelet agents and ACE inhibitors for PAD increases in the later lines of therapy. Which therapies have experienced market growth or decline over the key therapy periods studied? To what extent are key therapies prescribed concomitantly to recently treated patients? What has been the impact of recently approved drugs for PAD?


Primary patient-level data: This report provides quantitative findings from our analysis of data covering approximately 40 million lives and provides the most representative sample of U.S. treatment practice for Medicare and commercially insured patients. This report is delivered as a key findings slide deck and a dashboard that can be accessed using the Internet and presents claims that are less than six months old at the time of publication.

Patient Sample:Patients who are continuously enrolled for the complete two-year study period must meet the following condition: at least one claim with a diagnosis code for PAD (International Classification of Diseases, Ninth Revision [ICD-9] diagnostic codes 443.89, 443.90, 440.21, 440.22) during the study period.

Quantified lines of therapy analyses show exact share of each agent in each line of therapy, including rate of progression between lines and length of time patients are on each line..

Newly Diagnosed Patients:

- Patient share by drug class and key products across three lines of therapy, within one year of diagnosis.

- Patient flowcharts through one year of treatment for all first-line products, including progression rates and add/switch behavior.

- Polypharmacy and key concomitant therapies by line of therapy.

- Quarterly trending of patient share by line of therapy.

Recently Treated Patients:

- Quarterly snapshot of patient share by drug class and key products.

- Pathway to key therapy flowcharts tracking the preceding therapy patterns for all key therapies, including add/switch behavior.

- Brand source of business, including share for continuing, new (switches/adds), and new (initial therapy) business.

- Polypharmacy and key concomitant therapies.

- Drug persistence and compliance.

- Quarterly trends in patient share for all key therapies.

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