DRG epidemiologists estimate that 40% of epilepsy patients experience generalized-onset seizures (GOS). The most commonly prescribed early-line treatments for GOS are older antiepileptic drugs (AEDs), such as valproic acid, levetiracetam, topiramate, and lamotrigine.To date, perampanel is the only third-generation AED approved for generalized epilepsy. Neurologists consider many factors when choosing among the numerous first-, second-, and third-generation AEDs and must make adjustments throughout a patient’s disease course to achieve optimal seizure control. Understanding the evolving journey of epilepsy patients with GOS provides important context about the complex, saturated, and heavily generic drug market that developers of new AEDs will enter, should they pursue an expanded labeling for GOS. For the first time, our 2019 Treatment Algorithms series offers this GOS segmentation, as well as a companion study on partial-onset seizures (POS).


  • What patient shares do key therapies and brands garner by line of therapy in newly diagnosed epilepsy patients with GOS? What are the quarterly trends in prescribing among recently treated and newly diagnosed epilepsy GOS patients?
  • How have Fycompa, Trokendi XR, and Qudexy XR been integrated into the treatment algorithm, and what is their source of business?
  • What percentage of newly diagnosed epilepsy patients with GOS receive drug therapy within our tracking period, and how quickly do they receive it? What percentage of patients progress to later lines of therapy during our tracking period?
  • What percentage of epilepsy patients with GOS are treated with monotherapy versus combination therapy? What are the most commonly used combinations?
  • What are the product-level compliance and persistency rates among drug-treated patients with GOS?

Markets covered: United States

Real-world data: Longitudinal patient-level claims data analysis

Key companies: Eisai, Supernus Pharmaceuticals, Upsher-Smith

Key drugs covered: Fycompa, Trokendi XR, Qudexy XR, clonazepam, phenytoin, levetiracetam, lamotrigine, valproate

Key analysis provided:

  • Brand/therapy usage across a longitudinal patient sample.
  • Newly diagnosed patient analysis.
  • Treatment initiation and progression.
  • Line of therapy analysis.
  • Combination therapy analysis.
  • Source of business for recently treated patients.
  • Persistency and compliance analysis.
  • Product-level patient flowchart.


Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.

Table of contents

  • Epilepsy - Current Treatment - Detailed, Expanded Analysis: Treatment Algorithms: Claims Data Analysis - Generalized Onset Seizures (US)
    • Treatment Algorithms CDA-Epilepsy (Generalized Onset Seizures)-US-April 2019

Author(s): Shefali Gulati, MBA Pharm

Shefali Gulati, Associate analyst, is part of the Central Nervous System, Pain, and Ophthalmology team at Decision Resources Group.

She is responsible for performing extensive secondary market research and analysis for major pharmaceutical markets. She comes with one year of experience working on multiple client projects revolving around opportunity assessment, competitive landscape, pipeline analysis, and key product profiling. She holds a MBA degree in Pharmaceutical Management from the National Institute of Pharmaceutical Education and Research (NIPER) in India and Bachelor’s in Pharmacy from DIPSAR.

Related Reports

Epilepsy - Landscape & Forecast - Disease Landscape & Forecast

Epilepsy, which afflicts approximately 4.7 million people in the major pharmaceutical markets under study according to DRG epidemiology, is a heterogen...

View Details

Epilepsy | Disease Landscape and Forecast | G7 | 2020

Epilepsy, which afflicts approximately 4.7 million people in the major markets according to DRG epidemiology, is a heterogeneous condition requiring individualized treatment based largely on a...

View Details

Epilepsy - Special Topics - Epilepsy Special Topics New Treatments In Epilepsy US

More than two dozen antiepileptic drugs (AEDs) are available in the United States, yet approximately one-third of epilepsy patients are refractory to

View Details