Seborrheic dermatitis is a chronic inflammatory skin disorder characterized by scaly, erythematous, and itchy skin in sebum-rich areas of the body (e.g., scalp, face, upper chest). The severity of disease can range from mild dandruff to widespread patches of red, itchy, inflamed skin lesions, which place a social and psychological burden on patients. Topical antifungals are the entrenched treatment; topical corticosteroids are common second-line options, although safety and tolerability concerns render them suboptimal medications for longer-term symptom management. Novel nonsteroidal therapies, including topical phosphodiesterase-4 inhibitors (i.e., Arcutis Biotherapeutics’ topical roflumilast), are in clinical development. If efficacious, they stand to capitalize on the unmet need for additional effective and safe therapies in this space.
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