Immune checkpoint inhibitors have transformed the treatment algorithm for recurrent or metastatic non-nasopharyngeal squamous cell carcinoma of the head and neck (SCCHN) and diversified treatment options beyond standard Erbitux-based regimens. Merck & Co.’s Keytruda and Bristol-Myers Squibb’s Opdivo are already entrenched and good therapeutic options for previously treated recurrent or metastatic SCCHN. The 2019 label expansion of Merck & Co.’s Keytruda has revolutionized the choice of first-line therapy for SCCHN by offering better targeted therapeutic options with Keytruda regimens based on patient characteristics such as PD-L1 expression. The possibility of using immunotherapy with Keytruda frontline will shift current treatment practices.
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