Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the development and progressive enlargement of fluid-filled cysts in the kidneys. Particularly in the early stages, the disease is often asymptomatic and detectable only through diagnostic imaging of the kidney to reveal cysts. Until recently, treatment has focused on reducing blood pressure and pain and managing infection. However, the U.S. launch of Otsuka’s Jynarque (tolvaptan) in 2018 introduced the first disease-specific therapy for ADPKD. This therapy is approved for the treatment of ADPKD patients at risk of rapidly progressing. We examine how Jynarque’s launch has impacted ADPKD patient treatment and the challenges / opportunities that emerging therapies will face entering this market.
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Special Topics provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand. It supports clinical development decisions by identifying key attributes and assessing areas of unmet need. Insights into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities are provided.