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Retinal vein occlusion (RVO) is a major cause of blindness, and affected approximately 1.6 million patients in 2018 in the United States. Patients are segmented by the anatomic location of the occlusion, and therefore are classified as having branch, central, or hemi-retinal vein occlusion (BRVO, CRVO, HRVO, respectively). Because retinal vein occlusions compromise venous return from the retinal circulation, they may trigger retinal ischemia, macular edema and/or neovascularization. Intravitreally administered biologics targeting vascular endothelial growth factor (anti-VEGF agents; Roche/Genentech’s Avastin, Roche/Genentech’s Lucentis, Regeneron’s Eylea) and corticosteroids (Allergan’s Ozurdex) are used to treat macular edema following RVO. Although the pipeline for emerging RVO therapies is sparse, commercial opportunity exists for therapies with a longer dosing duration, greater efficacy, efficacy in treatment-resistant patients, and that are administered less invasively.
3 KOL interviews in April 2019
KEY COMPANIES COVERED
Regeneron, Roche/Genentech, Allergan, Novartis, Aerie Pharmaceuticals, Cerevast Medical, Taiwan Liposome Company, Kodiak Sciences
KEY DRUGS COVERED Avastin, Eylea, Lucentis, Ozurdex, brolucizumab, AR-1105, TLC399, KSI-301
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Natalie Taylor, is a Principal Business Insights Analyst with the central nervous system/ophthalmology disorders team at Decision Resources Group. She has over ten years of experience authoring primary and market research reports for pharmaceutical industry clients across multiple psychiatry, pain, neurology, and ophthalmology therapy areas. Prior to joining DRG, Dr. Taylor worked at QuintilesIMS as manager of the central nervous system portfolio of Disease Insights market forecasting offerings. She completed her in Physiology at Dartmouth College in Hanover, New Hampshire, where she studied the role of serotonergic neurons in the medullary raphe on modulating respiratory responses in mammals. She holds a in Biology from Dickinson College in Carlisle, Pennsylvania.