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Childhood absence epilepsy (CAE) is characterized by frequent and brief absence seizures in children aged 4-12 and is diagnosed in approximately 10-15% of all childhood epilepsies. Only a handful of antiepileptic drugs (AEDs) are believed to be effective in CAE, and only two of these drugs (ethosuximide and valproate) are approved to treat absence seizures. Treatment becomes more complicated if the patient also suffers from co-occurring generalized tonic-clonic (GTC) seizures. Moreover, all AEDs currently used for CAE are associated with clinical shortcomings in efficacy, safety, and/or delivery. Thus, ample opportunity exists for new and improved alternatives, renewing developers’ interest in this space.
Markets covered: United States, United Kingdom, France, and Germany.
Primary Research: Survey of 60 U.S. neurologists and 31 European neurologists.
Key Drugs Covered: Ethosuximide, valproate, lamotrigine, levetiracetam, topiramate, zonisamide.
Key metrics included:
Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. Two market scenarios are profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.
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"Niyati Khetarpal is an analyst on the Central Nervous System, Pain, and Ophthalmology team at ;In this role, she conducts extensive secondary research to analyze and forecast pharmaceutical markets, with specific expertise in patent research. Prior to joining the company, Niyati obtained her doctorate from the International Centre for Genetic Engineering and Biotechnology for her research on Dengue virus vaccines. She received the Fulbright-Nehru doctoral scholarship in 2014 for her research on Dengue and West Nile virus envelope ;