The most highly anticipated analgesic drugs in late-phase development belong to the anti-nerve growth factor (NGF) class: Pfizer / Eli Lilly’s tanezumab and Regeneron / Teva / Mitsubishi Tanabe’s fasinumab. As the first injectable biologics expected to launch in the crowded and highly generic oral chronic pain market, these drugs have the potential to disrupt the current later-line treatment algorithm of chronic pain patients. Despite demonstrations of impressive efficacy results in clinical trials, lingering concerns about the safety of this class may constrain prescribing. However, the need for less-addictive yet potent analgesics for chronic pain patients may lead physicians to overcome such concerns to provide robust analgesia to chronic pain patients without chronic use of opioid analgesics. We explore attitudes toward anti-NGF drugs and the potential disruption of treatment paradigms with the anticipated launch of these drugs.


  • How do physicians plan to prescribe the anti-NGF drugs? What prescription therapies or surgical treatments will be impacted by the availability of the anti-NGF drugs?
  • How have clinical trial data affected physicians’ attitudes toward the anti-NGF drugs’ safety profiles in chronic pain patients? What are the top reasons some physicians would refrain from prescribing the anti-NGF drugs?
  • To what extent do physicians differentiate between tanezumab and fasinumab, and what factors influence their preferences?

Geography: United States

Primary Research: Survey of 52 U.S. pain specialists and 50 U.S. rheumatologists

Key Drugs Covered: Tanezumab, fasinumab

Content Highlights: Physician willingness to prescribe anti-NGF drugs. Factors influencing use of anti-NGF drugs. Anticipated use of anti-NGF drugs and their expected impact on medical practice. Key obstacles to uptake of anti-NGF drugs.

PRODUCT DESCRIPTION: Special Topics uses quantitative primary research to assess evolving trends and market effects in dynamic disease areas. The report examines topics of high interest to an indication, such as delving into reasons driving physicians’ prescribing decisions or assessing physicians’ receptivity to emerging agents in order to better understand the nuanced dynamics in the indication.

Table of contents

  • Special Topics: How will Anti-NGF Therapies Disrupt Existing Pain Treatment Algorithms? (US)
    • Special Topics - How Will Anti-NGF Therapies Disrupt Existing Pain Treatment Algorithms (US)

Author(s): Joyce Spadafora, ALM

Joyce is a business insights analyst in Decision Resources Group’s central nervous systems and ophthalmology division, where she provides expert insight into commercial aspects of drug development and market sizing across psychiatric and pain indications. She has worked extensively in DRG’s schizophrenia and chronic pain content. Prior to joining DRG, Joyce spent several years in the biotech industry focused in research and development and in biotech consulting. Her project experience covered indications including psychiatry, pain, infectious diseases, respiratory, and ophthalmology. Beyond my therapeutic and industry knowledge, she holds a Masters in Extension Studies in Psychology from Harvard University and a in Mechanical Engineering with Biology from the Massachusetts Institute of Technology.

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