Acute heart failure (AHF) is characterized by the rapid onset or aggravation of symptoms of heart failure. The standard of care in AHF has remained largely unchanged since the 1970s, resulting in a highly genericized market. AHF patients continue to experience high rates of mortality and morbidity because no therapy to date has been able to improve hard clinical outcomes. This study evaluates how current therapies are differentiated based on their performance on key drug attributes and measures the impact of these attributes on the prescribing behavior of cardiologists. Revealing the relative importance of unmet needs helps identify the most attractive opportunities in AHF treatment.


  • Which drug attributes most strongly influence AHF drug selection?
  • How do cardiologists rate key current AHF therapies across select drug attributes?
  • Where are the hidden opportunities for drug development in the AHF therapy market?
  • Do U.S. and European cardiologists have different perceptions of the unmet need in the treatment of AHF?


Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.

Markets covered: United States, United Kingdom, France, Germany.

Primary research: Survey of 60 U.S. and 32 European cardiologists fielded in December 2019.

Key companies: Novartis, Johnson & Johnson, Pfizer.

Key drugs: Nitrate vasodilators, loop diuretics, inotropic sympathomimetics, PDE3 inhibitors, calcium sensitizers.

Table of contents

  • Detailed, Expanded Analysis Acute Heart Failure (US/EU)
    • Executive Summary
      • Unmet Need - Acute Heart Failure - Executive Summary - February 2020
    • Introduction
      • Overview
      • Methodology
      • Rationale for Treatment Drivers and Goals Selection
      • Rationale for Drug Selection
    • Treatment Drivers and Goals
      • Key Findings: Attribute Importance
      • Key Findings: Stated vs. Derived Importance
    • Product Performance Against Treatment Drivers and Goals
      • Key Findings
    • Assessment of Unmet Need
      • Key Findings: Unmet Need in Acute Heart Failure
      • Key Findings: Unmet Need in Acute Heart Failure and Related Indications
    • Opportunity Analysis
      • Areas of Opportunity in the Acute Heart Failure Market and Emerging Therapy Insights
        • Opportunity: A Novel Agent That Significantly Reduces the Rate of Cardiovascular Mortality in Acute Heart Failure
        • Opportunity: A Novel Agent That Reduces the Rate of Rehospitalization for Heart Failure
        • Opportunity: A Novel Agent That Shows Significant Improvement in the Incidence of Worsening Heart Failure and Reduces the Length of Hospital Stay
    • Target Product Profiles
      • Assessing Drug Development Opportunities
      • Target Product Profile Methodology
      • Attribute Importance and Part-Worth Utilities
        • Acute Heart Failure Target Product Profile: Attribute-Level Part-Worth Utilities
      • Conjoint Analysis-Based Simulation of a Market Scenario
        • Market Scenario
    • Appendix
      • Bibliography

Author(s): Dwaipayan Chatterjee, M.Pharm

Dwaipayan Chatterjee is an Analyst in the Cardiovascular, Metabolism Renal and Hematology disease team at Decision Resources Group. He holds a degree with specialization in Pharmaceutical Chemistry from Birla Institute of Technology & Science, Pilani, Rajasthan, India. Prior joining DRG, he worked as an Equity Analyst for the Healthcare sector with Market Realist working on competitive intelligence and analysis of pharmaceutical financial data. He also worked as a market research analyst for Mordor Intelligence with experience of market sizing, forecasting, and analyzing market dynamics.

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