Market Outlook

The multiple myeloma landscape is witnessing successive label expansions. The availability of premium-priced branded agents prescribed in not just doublet and triplet regimens but also as quadruplets is driving the sales of multiple myeloma drugs. While Celgene’s Revlimid and Janssen / Takeda Pharmaceutical’s Velcade remain the cornerstones of therapy for multiple myeloma, emerging agents such as Sanofi / ImmunoGen’s isatuximab, Oncopeptides’ Ygalo, Karyopharm Therapeutics’ Xpovio / selinexor, BMS / Bluebird Bio’s idecabtagene vicleucel / bb2121, and GlaxoSmithKline’s belantamab mafodotin / GSK2857916 are pursuing initial approvals. There is immense clinical and commercial potential to be exploited in multiple myeloma for therapies that have improved efficacy, novel mechanisms of action, and cater to underserved patient segments.

Questions Answered

  • How has the approval of Janssen’s Darzalex and Bristol-Myers Squibb / AbbVie’s Empliciti impacted the multiple myeloma market? How important will these agents become over the forecast period?
  • Revlimid and Velcade are widely used for the current treatment of multiple myeloma, but how will the use of these agents change over the forecast period? What impact will generic entries of these pivotal agents have on the multiple myeloma market?
  • What are thought leaders’ opinions on agents in Phase III development, such as Sanofi / ImmunoGen’s isatuximab, BMS / Bluebird Bio’s idecabtagene vicleucel / bb2121, GlaxoSmithKline’s belantamab mafodotin / GSK2857916, and Janssen’s subcutaneous formulation of Darzalex?
  • What impact will these agents have on the multiple myeloma market? What are the drivers and constraints in the multiple myeloma market, and how will the market evolve over the forecast period?

Product Description

Disease Landscape & Forecast: Comprehensive market intelligence providing world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Table of contents

  • Disease Landscape & Forecast
    • Key Findings
      • Multiple Myeloma - Key Findings
    • Key Updates
      • December 2019
      • August 2019
      • June 2019
      • December 2018
      • October 2018
      • September 2018
      • May 2018
      • March 2018
    • Market Outlook
      • Key Findings
        • Key Findings
      • Market Drivers and Constraints
        • What Factors Are Driving the Market for Multiple Myeloma?
        • What Factors Are Constraining the Market for Multiple Myeloma?
      • Segment-Specific Trends
        • Smoldering Multiple Myeloma
        • First-Line Transplant-Eligible Multiple Myeloma
        • First-Line Transplant-Ineligible Multiple Myeloma
        • Relapsed/Refractory Multiple Myeloma
    • Forecast
      • Market Forecast Downloads
      • Market Forecast Assumptions
    • Etiology and Pathophysiology
      • Disease Overview
      • Disease Pathophysiology
        • Overview
      • Risk Factors
      • Staging and Classification
        • Classification of Multiple Myeloma
        • Staging of Multiple Myeloma
      • Key Pathways and Drug Targets
    • Epidemiology
      • Key Findings
      • Epidemiology Populations
        • Diagnosed Incident Cases
        • Diagnosed Incident Cases of Multiple Myeloma by Symptoms
        • Asymptomatic Multiple Myeloma Progression to Symptomatic Multiple Myeloma
        • Drug-Treatable Populations
        • Drug-Treated Populations
    • Current Treatment
      • Key Findings
      • Treatment Goals
      • Key Current Therapies
        • Overview
        • Immunomodulatory Agents
        • Proteasome Inhibitors
        • Histone Deacetylase Inhibitors
        • Cell-Surface-Targeted Agents
      • Medical Practice
        • Asymptomatic Multiple Myeloma
        • First-Line Transplant-Eligible Multiple Myeloma
        • First-Line Transplant-Ineligible Multiple Myeloma
        • Relapsed/Refractory Multiple Myeloma
        • Region-Specific Treatment Practices
    • Unmet Need
      • Attainment of Unmet Needs
        • Current and Future Attainment of Unmet Needs in Multiple Myeloma
    • Emerging Therapies
      • Key Findings
      • Key Emerging Therapies
        • Apoptosis-Inducing Agents
        • Cell-Surface-Targeted Agents
        • Selective Inhibitors of Nuclear Export
        • CAR T-Cell Therapies
        • Antibody-Drug Conjugates
      • Early-Phase Pipeline Analysis
    • Access and Reimbursement
      • Region-Specific Reimbursement Practices
        • United States
        • EU5
        • Japan
        • Looking for More?
    • Methodology
      • Bottom-Up Forecasting Overview
        • Patient Populations
        • Drug- and Regimen-Specific Assumptions
      • Bottom-Up Forecasting Assumptions
        • General Sources of Data
        • General Statements About Pricing
        • Dosing, Cycles of Therapy, and Compliance
        • Generic Erosion
        • Biosimilar Erosion
        • Out-Year Forecasting
        • Emerging Therapy Prices
      • Primary Market Research
        • Experts Interviewed
    • Appendix
      • Multiple Myeloma Bibliography

Author(s): Snigdha Gupta, Ph.D; Nishant Kumar, MPH

Dr. Snigdha Gupta is a Lead Analyst in the oncology team at Decision Resources Group with expertise in multiple oncology indications including non-small cell lung cancer and multiple myeloma. Prior to joining DRG, Dr. Snigdha Gupta was a subject matter expert in immune-oncology, autoimmunity and dealt in generating in-depth framework based scientific analyses for client projects. In her previous organizations, she was involved in the planning and execution of the IND enabling preclinical studies. She has been instrumental in the stage-up of two small molecules at Bioxcel Therapeutics and Daiichi Sankyo Pharma India Pvt. Ltd. Dr. Gupta holds in infectious diseases from the Indian Institute of Chemical Biology, Jadavpur University, Kolkata while her post-doctoral fellowship is from the Mucosal immunology labs of National Institute of Immunology, New Delhi.

Nishant is a senior epidemiologist and head of oncology within the epidemiology team at Decision Resources Group. He also covers some CNS diseases, including Alzheimer’s disease and dementia. His key interests are developing interactive patient flows, and modelling disease progression to forecast commercially relevant drug-treatable incident and prevalent populations. Nishant also spends a lot of time collaborating with clients to help answer more specific questions through custom work and consulting projects. His qualifications include an MSc in Public Health with specialization in epidemiology and statistics from King’s College London, and a BSc in Medical Studies from the University of Birmingham.

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