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Diabetic macular edema (DME) occurs as a consequence of diabetes. It typically develops in the advanced stage of diabetic retinopathy and is characterized by leaking fluid from abnormal blood vessels in the eye, which can lead to swelling of the macula and visual impairment. Intravitreal vascular endothelial growth factor (VEGF) inhibitors, such as Regeneron/Bayer HealthCare’s Eylea, Roche/Genentech/Novartis’s Lucentis, and Roche/Genentech’s Avastin, are the most common pharmacotherapies used to treat DME because of their proven efficacy and safety. Allergan’s Ozurdex and Alimera Sciences’ Iluvien, two long-acting corticosteroid implants, are also used to treat DME. However, all of these drugs present clinical shortcomings in efficacy, safety, and/or delivery, creating opportunities for new and improved alternatives. Our content examines the key treatment drivers and analyzes the greatest areas of unmet need and thereby the opportunities in this space.
Unmet Need: Provides quantitative insight into U.S. and European physicians’ perceptions of key treatment drivers and goals and the current level of unmet need for a specific disease. Commercial opportunities are analyzed, and the extent to which emerging therapies may capitalize on these opportunities is evaluated.
Markets covered: United States, United Kingdom, France, Germany
Primary research: Survey of 60 ophthalmologists in the United States and 32 ophthalmologists in Europe
Key companies: Roche/Genentech, Novartis, Regeneron, Bayer HealthCare, Allergan, Alimera Sciences
Key drugs:Lucentis, Eylea, Avastin, Ozurdex, Iluvien, triamcinolone
Key metrics included:
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"Niyati Khetarpal is an analyst on the Central Nervous System, Pain, and Ophthalmology team at ;In this role, she conducts extensive secondary research to analyze and forecast pharmaceutical markets, with specific expertise in patent research. Prior to joining the company, Niyati obtained her doctorate from the International Centre for Genetic Engineering and Biotechnology for her research on Dengue virus vaccines. She received the Fulbright-Nehru doctoral scholarship in 2014 for her research on Dengue and West Nile virus envelope ;