Following the 2017 launches of two atopic dermatitis novel therapies, Pfizer’s topical PDE-4 inhibitor Eucrisa (crisaborole) and Sanofi/Regeneron’s IL-4/13 inhibitor Dupixent (dupilumab), the U.S. treatment and market access landscape for atopic dermatitis is evolving. Topical agents are the mainstay of treatment for atopic dermatitis, especially for patients with mild to moderate disease. Eucrisa provides a much needed alternative to topical corticosteroids and topical calcineurin inhibitors. Dupixent has given moderate to severe atopic dermatitis patients a promising targeted therapy option, with AstraZeneca/Leo Pharma’s tralokinumab, Galderma’s nemolizumab, Vanda’s tradipitant, and multiple JAK inhibitors potentially strengthening the field in the near future. Payers look to manage utilization of therapies to control costs in the wake of the more recent premium-priced entrants in this previously genericized market.
- What are current prescribing practices for atopic dermatitis, and how are they impacted by payer policy?
- How has the market entry of Eucrisa and Dupixent influenced physician prescribing and payer policy?
- How will dermatologists’ prescribing of established agents by line of therapy shift with the recent entry of Eucrisa and Dupixent?
- What are payer and physician perspectives on promising but costly emerging agents such as tralokinumab, nemolizumab, tradipitant, and JAK inhibitors?
Geography: United States
Primary Research: Survey of 100 U.S. dermatologists Survey of 30 U.S. managed care organization (MCO) pharmacy and medical directors (PDs/MDs)
Key Drugs Covered: Dupixent, Eucrisa, Protopic, Elidel, CellCept, Neoral/Sandimmune, Temovate/Olux/Clobex, Aristocort/Kenalog, tralokinumab, nemolizumab, tradipitant, baricitinib, upadacitinib, abrocitinib
Content Highlights: Reimbursement and contracting Access and prescribing Special topics Opportunities and challenges for emerging therapies
U.S. Access & Reimbursement provides in-depth insight on the impact of payer policy on prescribing behavior so that clients can build their market access strategy and optimize their brand positioning. This analysis of primary market research with physician specialists and U.S. payers helps clients stay up-to-date on restriction policies, gauge payer and prescriber attitudes toward specific therapies, identify opportunities where brands can capture patient share through market access, and maximize opportunities for emerging therapies by learning how previous brands gained favorable reimbursement or why they stumbled.
- Detailed, Expanded Analysis (US)
- Access & Reimbursement Atopic Dermatitis US May 2019
Author(s): Ritesh Gupta, PhD; Chris Lewis
Ritesh Gupta is a Lead Analyst on the immune and inflammatory disorders team at Decision Resources Group, whose work focuses primarily on Psoriatic Arthritis, Ulcerative Colitis and Crohn’s Disease. He holds a degree in Cell Biology from Max Delbrück Center for Molecular Medicine, Berlin, where he worked on development of novel inhibitors for HGF/MET signaling pathways. Prior to joining DRG, Ritesh has worked as an assistant manager with BioXcel corporation and provided insights on various consulting projects. He was also associated with GVK Biosciences and worked on drug repurposing projects.
Chris Lewis serves as primary research manager, Access and Reimbursement, with responsibility for coordination, content review and content generation of the market access and reimbursement insights at DRG. Content is based on online surveys of managed care organizations and physicians and expert analysis of reimbursement and prescribing patterns of key therapies treating various disease states. Lewis was an analyst/senior analyst for the group’s HealthLeaders-InterStudy subsidiary for eight years, specializing in the managed care and pharmacy benefit management industries. Throughout her tenure, she has produced the Health Plan Analysis reports for California, New York, New Jersey, Connecticut, and Pennsylvania and authored DRG’s series of pharmacy benefit manager profiles. She has also conducted numerous webinars for the group. She is a seasoned journalist with a in communications from California State University, Sacramento.