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Acute myeloid leukemia (AML) is the most common form of adult leukemia and has the lowest five-year overall survival rates of all blood cancers. Historically, AML treatment has been dominated by chemotherapy followed by allo-SCT in eligible patients. However, following a flurry of drug approvals in 2017 and 2018, the AML treatment landscape is undergoing a transformation. The entry of novel agents into the treatment paradigm will enable the increasingly personalized treatment of patients, based on the characteristics of their disease and specific biomarkers. However, several areas of unmet need remain. Notably, patients unfit for intensive chemotherapy induction and relapsed/refractory AML patients offer significant commercial opportunity for innovative agents.
Label expansions and new drug approvals (e.g., FLT3 inhibitors, apoptosis-inducing agents) will fuel substantial growth of the AML therapy market over the 2017-2027 forecast period. This report provides insight on how treatment options for AML are likely to change over the 2017-2027 forecast period. It also analyzes the current and future earnings potential of AML therapies.
Markets covered: United States, France, Germany, Italy, Spain, United Kingdom, and Japan.
Primary research: 17 country-specific interviews with thought leaders.
Epidemiology: Diagnosed incident cases of de novo AML and AML with MDS-related changes.
Population segments in market forecast: First-line AML, younger patients (aged < 60); first-line AML, older patients (aged ≥ 60); second-line AML, younger patients (aged < 60); second-line AML, older patients (aged ≥ 60); third-line AML.
Emerging therapies: Phase III: 11 drugs; Phase II: 27 drugs.
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Jorrit Schäfer, , is a business insights analyst at Decision Resources Group. Prior to joining DRG, Dr. Schäfer worked as a postdoctoral research associate at Imperial College London, where he studied the impact of antibiotic stress on RNA repair in bacteria. Dr. Schäfer holds a in molecular medicine and a in molecular cell biology from Imperial College London.
Atul Sharma started working in Decision Resources Group as an intern in early 2016 and currently works as an associate epidemiologist. He performs fully documented systematic reviews of both published and grey literature on the epidemiology of assigned diseases and their risk factors to estimate incidence/prevalence over a 10-30 year period. He produces analyses for pharmaceutical drug developers on the descriptive epidemiology of major drug indications in mature and developing markets. He holds a Master’s in Public Health degree from School of Public Health, Post-Graduate Institute of Medical Education and Research and a Bachelor’s in dental surgery from MN DAV Dental College & Hospital.