The treatment of renal cell carcinoma has long been dominated by targeted treatments, including mTOR and angiogenesis inhibitors. However, the introduction of immune checkpoint inhibitors has diversified treatment options. The treatment landscape for renal cell carcinoma is rapidly moving toward combination approaches, as witnessed by the approvals of Lenvima/Kisplyx (Eisai) plus Afinitor (Novartis) in 2016, Opdivo plus Yervoy (Bristol-Myers Squibb/Ono Pharmaceutical) in 2018, and Keytruda (Merck & Co.) plus Inlyta (Pfizer) in 2019. As combination regimens experience uptake in the larger and more commercially lucrative first-line advanced setting, drug developers should gain an understanding of the key drivers and obstacles to maximize uptake.
- What are the drug-treatment rates across clinically and commercially relevant renal cell carcinoma patient populations?
- How are the new drug entrants performing in the face of existing small-molecule TKIs such as Votrient and Sutent for advanced disease?
- What is the uptake of Opdivo plus Yervoy in previously untreated intermediate- or poor-risk advanced renal cell carcinoma, according to U.S. medical oncologists?
- What factors drive or constrain the prescribing habits of U.S. medical oncologists?
Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that marketers can create specific messaging around these treatment dynamics to more effectively increase or defend their market position.
Geographies: United States
Primary Research: Survey of 100 medical oncologists in the United States
Key Drugs Covered: Opdivo, Yervoy, Cabometyx, Sutent, Votrient, Inlyta, Afinitor, Lenvima
- Detailed, Expanded Analysis (US)
- Current Treatment Physician Insights Renal Cell Carcinoma US August 2019
Author(s): Grace Mitchell, M.Res; Joshua Dawkins, M.Pharmacol., PhD
is a business insights analyst in the oncology team at Decision Resources Group. Ms. Mitchell previously worked as an analyst at financial PR firm, Tulchan Communications, where she provided news on the pharmaceutical sector from a commercial perspective. Prior to this, Ms. Mitchell was a project assistant within the consulting team at DRG-Abacus where she learnt about HEOR and market access. Ms. Mitchell obtained her Masters in Cancer Sciences from the University of Birmingham. The degree focused on the expression of immune checkpoints in DLBCL. She also holds a in Biomedical Science from the University of Reading.
Joshua Dawkins, , is a Business Insights Analyst in the oncology team at Decision Resources Group. Prior to joining DRG, Dr. Dawkins obtained his doctorate in molecular biology at the Barts Cancer Institute, Queen Mary University of London, where he investigated the roles of epigenetic histone modifiers in pancreatic ductal adenocarcinoma. Dr. Dawkins also holds a Master of Pharmacology degree awarded by the University of Bath, and completed a one-year professional placement within the oncology team at MedImmune.