Breast Cancer | Unmet Need | Detailed, Expanded Analysis: Advanced/Metastatic Triple-Negative Breast Cancer

Publish date: August 2019

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Triple-negative breast cancer (TNBC) is a patient population with high unmet need given the poor outcomes associated with current treatment options and the historic lack of targeted therapies available. The treatment landscape has evolved in recent years with the approval of PARP inhibitors Lynparza and Talzenna for patients with germline BRCA mutations and Tecentriq plus Abraxane for PD-L1-positive patients. Despite the availability of new therapies, significant clinical and commercial opportunity remains for the development of targeted and/or immune-based therapies to improve survival outcomes. Our unmet need module analyzes the key drivers of prescribing and assesses how emerging therapies may capitalize on these opportunities.

Questions Answered

  •  What are the key drivers that are most likely to influence treatment uptake for advanced / metastatic TNBC?
  •  How do current therapies perform on key treatment drivers and goals for advanced / metastatic TNBC?
  • What are the prevailing areas of unmet need and opportunities in advanced / metastatic TNBC?
  • What trade-offs across different clinical attributes and price are acceptable to U.S. and European medical oncologists for a hypothetical therapy in newly diagnosed advanced / metastatic TNBC?

Product Description

Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. Two market scenarios are profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.

Markets covered: United States, United Kingdom, France, Germany

Primary research: Survey of 60 U.S. and 30 European medical oncologists fielded in May 2019.

Key companies: Roche / Genentech, Celgene, AstraZeneca, Pfizer, Eisai.

Key drugs: Tecentriq, Abraxane, Lynparza, Talzenna, Halaven, Avastin.

Table of contents

  • Detailed, Expanded Analysis: Advanced/Metastatic Triple-Negative Breast Cancer
    • Introduction
      • Overview
      • Methodology
      • Rationale for Treatment Drivers and Goals Selection
        • Efficacy
        • Safety and Tolerability
        • Convenience of Administration
      • Rationale for Drug Selection
    • Treatment Drivers and Goals
      • Key Findings: Attribute Importance
      • Key Findings: Stated vs. Derived Importance
    • Product Performance Against Treatment Drivers and Goals
      • Key Findings
    • Assessment of Unmet Need
      • Key Findings: Unmet Need in Advanced or Metastatic Triple-Negative Breast Cancer
      • Key Findings: Unmet Need in Advanced or Metastatic Triple-Negative Breast Cancer and Related Indications
    • Opportunity Analysis
      • Areas of Opportunity in the Advanced or Metastatic Triple-Negative Breast Cancer Market and Emerging Therapy Insights
        • Opportunity: A Novel Agent with Improved Survival Benefit
        • Opportunity: A New Therapy That Improves Progression-Free Survival
        • Opportunity: A Novel Agent with Improved Tumor Response
        • Opportunity: A Novel Therapy with a Better Safety and Tolerability Profile
    • Target Product Profiles
      • Assessing Drug Development Opportunities
      • Target Product Profile Methodology
      • Attribute Importance and Part-Worth Utilities
        • First-Line Advanced or Metastatic Triple-Negative Breast Cancer Target Product Profile: Attribute-Level Part-Worth Utilities
      • Conjoint Analysis-Based Simulations of Market Scenarios
        • Scenario 1
        • Scenario 2
    • Appendix
      • Bibliography

Author(s): Priti Girotra, M.Pharm., Ph.D

Priti Girotra, , is an analyst in the oncology team at Decision Resources Group and has authored insightful content on multiple indications including Non-Small-Cell Lung Cancer, Colorectal Cancer, Gastroesophageal Cancer, Malignant Melanoma, and Multiple Myeloma. Prior to joining DRG, Dr. Girotra conducted her research on formulation optimization of nanoparticles containing triptan derivatives for effective brain targeting and therapeutic management of migraine, under a DST-INSPIRE Fellowship at University of Science & Technology, Hisar, India.