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Male hypogonadism (low testosterone) is a condition characterized by impaired spermatogenesis and low serum testosterone. In adult men, low testosterone can be caused by intrinsic abnormalities in the testes or changes in pituitary or hypothalamic upstream signaling pathways contributing to testosterone biosynthesis. Age and comorbidity (e.g., obesity or type 2 diabetes) driven declines in testosterone levels represent the majority of cases of low testosterone in adult men. Testosterone replacement therapy (TRT), which aims to increase overall serum testosterone levels, is the cornerstone therapy for low testosterone and is primarily administered via injection or topical means. However, a key drawback of TRTs is decreased spermatogenesis, and some alternative therapies for low testosterone focus on the stimulation of gonadotropins in effort to preserve fertility. Additionally, the FDA has recently cautioned against the use of TRT due to the possibility of increased cardiac risk, and this study will evaluate potential changes to physician prescribing and treatment strategies through real-world data analyses.
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Michael is a business insights analyst on the Infectious, Niche, and Rare Diseases team. He has authored reports on cystic fibrosis, nonalcoholic steatohepatitis, vaccines, and respiratory syncytial virus, and will author a report on cytomegalovirus. He also provides coverage for Decision Resources’ Company & Drug Insights covering anti-infectives, vaccines, and transplant therapy areas. Michael received his Bachelor’s degree from Hunter College with a dual major in biology and biochemistry. He received his in biochemistry from Boston University School of Medicine. His postdoctoral research was carried out at Brigham and Women’s Hospital/Harvard Medical School, with a focus on identifying novel pathways regulating thermogenesis in search of a therapeutic for obesity and diabetes.