Idiopathic pulmonary fibrosis (IPF) is one of the most common interstitial lung diseases and is characterized by an irreversible loss of lung function. Roche’s pirfenidone (Esbriet) was the first disease-modifying therapy (DMT) approved for IPF, followed soon after by Boehringer Ingelheim’s nintedanib (Ofev); these therapies set the stage for fierce competition in the IPF therapy market. We explore this evolving space, analyzing the clinical and commercial outlook for pirfenidone and nintedanib. We assess emerging therapies, including FibroGen’s IV-administered pamrevlumab and Galapagos’s oral autotoxin inhibitor GLPG-1690. We also examine current medical practice and identify the areas of pressing unmet need in the treatment of the disease.


  • How will the size of the IPF population change through 2029? How large are the key subpopulations? What percentage of the IPF population receives drug treatment?
  • How do interviewed experts view the clinical profiles of Esbriet and Ofev, and what factors drive or constrain their use? What are the most pressing unmet clinical needs in the management of IPF, according to experts?
  • Which emerging therapies do IPF experts consider most promising? If approved, how would emerging therapies influence the management of IPF and the market position of Ofev and Esbriet? What is the commercial potential of pamrevlumab and GLPG-1690?

Table of contents

  • Disease Landscape & Forecast
    • COVID-19
    • Commercial Outlook
      • Key Findings
      • Drivers and Constraints
        • What Factors Are Driving the Market for Idiopathic Pulmonary Fibrosis?
        • What Factors Are Constraining the Market for Idiopathic Pulmonary Fibrosis?
      • Drug-Class-Specific Trends
        • Antifibrotics
        • Tyrosine Kinase Inhibitors
        • Connective Tissue Growth Factor Inhibitors
        • Autotaxin Inhibitors
      • Alternative Market Scenarios
    • Forecast
    • Etiology and Pathophysiology
      • Disease Overview
      • Etiology
      • Pathophysiology
        • Role of Inflammation
      • Disease Progression
      • Disease Staging
      • Symptoms and Complications
        • Symptoms and Complications of Idiopathic Pulmonary Fibrosis
      • Key Pathways and Drug Targets
    • Epidemiology Overview
      • Introduction
        • Key Findings
        • Key Updates
      • Epidemiology Populations
        • Diagnosed Prevalent Cases
        • Drug-Treated Prevalent Cases
        • Severity Stages
        • Comorbidities
    • Current Treatment Overview
      • Key Findings
        • Key Findings
      • Diagnosis
        • Diagnosis of Idiopathic Pulmonary Fibrosis
        • Diagnostic Tests and Criteria
      • Treatment Goals
      • Key Current Therapies
        • Overview
        • Antifibrotics
        • Tyrosine Kinase Inhibitors
        • Combination of Pirfenidone and Nintedanib
        • Other Medications Used to Treat Idiopathic Pulmonary Fibrosis
      • Medical Practice
        • Overview
        • Region-Specific Treatment Practices
    • Unmet Need Overview
      • Current and Future Attainment of Unmet Needs in Idiopathic Pulmonary Fibrosis
    • Emerging Therapies Overview
      • Introduction
        • Key Findings
      • Key Emerging Therapies
        • Connective Tissue Growth Factor Inhibitors
        • Recombinant Human Pentraxin-2
        • Autotaxin Inhibitors
      • Early-Stage Pipeline Analysis
      • Symptomatic or Acute Therapies in Development for Idiopathic Pulmonary Fibrosis
      • Key Discontinuations and Failures in Idiopathic Pulmonary Fibrosis
      • Patient Registries
        • Patient Organizations
      • Orphan Drug Designation
        • Orphan Drug Provisions: United States
        • Orphan Drug Provisions: Europe
    • Access and Reimbursement Overview
      • Region-Specific Reimbursement Practices
        • United States
        • EU5
        • Looking for More?
    • Methodology
      • Bottom-Up Forecasting Overview
        • Patient Populations
        • Drug-Specific Assumptions
      • Bottom-Up Forecast Assumptions
        • General Sources of Data
        • General Statements About Pricing
        • Dosing, Days of Therapy, and Compliance
        • Generic Erosion
        • Out-Year Forecasting
        • Emerging Therapy Prices
      • Primary Market Research
        • Experts Interviewed
    • Appendix
      • Idiopathic Pulmonary Fibrosis Bibliography

Author(s): Nuno Tiago Giao Antunes, PhD; Devashri Mukherjee, MPH; Natasha Bardhan, M.Pharm

Nuno T. Antunes, ,  is senior business insights analyst on the Infectious, Niche, and Rare Diseases team at Decision Resources Group, specializing in antibacterial agents. Previously, he was a Latin America Market Access senior analyst in the Global Market Access Insights Team, where he developed expertise in market access, pricing and reimbursement, health technology assessment, and health policy. Nuno holds a in animal health from the Universidad de las Palmas de Gran Canaria, Spain, and a degree from the Universidade de Trás-os-Montes e Alto Douro, Portugal. Prior to joining DRG, he conducted research in antimicrobial resistance and antimicrobial development, and worked in the medical devices industry as a scientist.

Research enthusiast with a flair for academic writing, member of the DRG family since April 2015 and working from the India office. Started off career with a bachelor’s in Dental Surgery followed by a master’s in Public health; having primarily worked in the hospital setting as a Research Consultant prior to DRG and with 10 international publications to my credit.

Natasha Bardhan is a Research Associate for the Infectious, Niche, & Rare Diseases (INRD) team at Decision Resources. Natasha Bardhan holds a bachelor’s degree in Pharmacy from DIPSAR, New Delhi and has completed her master’s in Pharmaceutics from Amity University, Noida. Prior to joining DRG, she worked as a Senior Associate at WNS (Healthcare) for two and a half years. She has worked on multiple client projects involving patents, sales and forecasting, pipeline analysis, keywords research and product/company profiling.

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