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Research & Reports

Searching in Biopharma (1958)

Myelofibrosis | Landscape & Forecast | Disease Landscape & Forecast

Myelofibrosis | Landscape & Forecast | Disease Landscape & Forecast

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MARKET OUTLOOK. Myelofibrosis is a hematological malignancy characterized by the disrupted production of blood cells and bone marrow scarring; symptoms include severe anemia, weakness, fatigue, and splenomegaly. Incyte/Novartis’s Jakafi/Jakavi is the first and only drug approved for myelofibrosis (MF) in the United States and EU5. Although it offers a therapeutic option for patients with MF, the drug is associated with high discontinuation rates and a loss of response (i.e., patients become refractory to treatment). Furthermore, not all patients benefit from Jakafi/Jakavi, nor does the agent address all MF symptoms (e.g., anemia). Therefore, significant market opportunity remains for safe and tolerable treatments that can effectively manage the full spectrum of symptoms—thereby minimizing the need for polypharmacy over long periods of time—as well as for treatment options for patients with baseline thrombocytopenia and anemia.

QUESTIONS ANSWERED. What are the key diagnostic challenges in MF? What are common misdiagnoses, and how frequently does misdiagnosis occur? What are the sizes of the U.S. and EU5 diagnosed prevalent and incident primary and secondary MF populations? What are the distributions of risk level among diagnosed incident and prevalent cases of primary MF? How will novel therapies impact the treatment algorithm for MF, and which MF patients will be served by these treatment options in 2027? What are the key unmet needs and areas of commercial opportunity for MF? How well will the MF pipeline address these needs?

PRODUCT DESCRIPTION Niche & Rare Disease Landscape & Forecast. Comprehensive market intelligence providing world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Table of contents

  • Disease Landscape & Forecast
    • Commercial Outlook
      • Key Findings
      • Drivers and Constraints
        • What Factors Are Driving Sales in Myelofibrosis?
        • What Factors Are Constraining Sales in Myelofibrosis?
      • JAK Inhibitor - Specific Trends
      • Alternative Market Scenarios
    • Forecast
    • Etiology and Pathophysiology
      • Disease Overview
      • Etiology
      • Pathophysiology
      • Clinical Presentation of Myelofibrosis
      • Key Pathways and Drug Targets
    • Epidemiology
      • Key Findings
        • Key Updates
      • Epidemiology Populations
        • Diagnosed Incident Cases of Myelofibrosis
        • Diagnosed Prevalent Cases of Myelofibrosis
        • Diagnosed Incident Cases of Primary Myelofibrosis
        • Diagnosed Prevalent Cases of Primary Myelofibrosis
        • Diagnosed Incident Cases of Myelofibrosis by IPSS Risk Group
        • Diagnosed Prevalent Cases of Myelofibrosis by DIPSS Risk Group
        • Diagnosed Incident Cases of Primary Myelofibrosis by Comorbidity
        • Diagnosed Prevalent Cases of Primary Myelofibrosis by Comorbidity
        • Diagnosed Incident Cases of Primary Myelofibrosis by Biomarker Status
        • Diagnosed Prevalent Cases of Primary Myelofibrosis by Biomarker Status
        • Drug-Treated Prevalent Cases of Myelofibrosis
    • Current Treatment
      • Key Findings
      • Diagnosis
        • Treatment Providers and Referral Patterns
      • Disease Staging
      • Treatment Goals
      • Key Current Therapies
        • Overview
        • JAK Inhibitors
        • Cytoreductive Therapies
        • Erythropoiesis-Stimulating Agents
        • Immunomodulatory Drugs
        • Interferons
        • Androgens
        • Red Blood Cell Transfusions
        • Hypomethylating Agents
        • Allogeneic Hematopoietic Stem-Cell Transplantation
      • Medical Practice
        • Overview
        • Region-Specific Treatment Practices
    • Unmet Need Overview
      • Current and Future Attainment of Unmet Needs in Myelofibrosis
    • Emerging Therapies
      • Key Findings
      • Key Emerging Therapies
        • Notable Developments Among Key Emerging Therapies for Myelofibrosis
        • JAK Inhibitors
        • TGFβ Inhibitors
      • Early-Phase Pipeline Analysis
        • Notable Developments in the Early-Phase Pipeline for Myelofibrosis
      • Patient Registries
        • Patient Organizations
    • Access & Reimbursement Overview
      • Region-Specific Reimbursement Practices
        • United States
        • EU5
      • Looking for More?
    • Methodology
      • Bottom-Up Forecasting Overview
        • Patient Populations
        • Drug-Specific Assumptions
      • Bottom-Up Forecast Assumptions
        • General Sources of Data
        • General Statements About Pricing
        • Dosing, Days of Therapy, and Compliance
        • Out-Year Forecasting
        • Emerging Therapy Prices
      • Primary Market Research
        • Experts Interviewed
    • Appendix
      • Myelofibrosis Bibliography

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  • Pub Date: November 2018
  • Author(s): Laura Darnieder; Narendra Parihar
  • Laura Darnieder is a Business Insights Analyst on the Infectious, Niche, and Rare Diseases team at Decision Resources Group, where she is focused on providing market forecasts within the niche biopharmaceutical space. Prior to joining DRG, Laura earned a in Neuroscience from Tufts University Sackler School of Graduate Biomedical Sciences. Her research focused on the role of stress neuropeptides and inhibitory signaling in alcohol dependence and drug addiction. She also holds a , summa cum laude, in Psychobiology and Linguistics from Binghamton University (SUNY).

  • Narendra is an associate epidemiologist within the epidemiology team at Decision Resources Group. Narendra specializes in developing epidemiological forecasts for multiple indications within the DRG syndicated portfolio. His qualifications include an MPH with specialization in Health Policy, Economics and Finance from the Tata Institute of Social Sciences, Mumbai, and a Bachelor’s degree in Dentistry from the Rajasthan University of Health Sciences.

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