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Research & Reports

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Multiple Myeloma | Landscape & Forecast | Disease Landscape & Forecast

Multiple Myeloma | Landscape & Forecast | Disease Landscape & Forecast

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Market Outlook

Celgene’s Revlimid and Janssen/Takeda Pharmaceutical’s Velcade are the cornerstones of therapy for multiple myeloma. Successive label expansions have driven significant commercial reward for some well-entrenched current therapies. Emerging agents such as AbbVie/Roche/Genentech’s Venclexta/Venclyxto, Karyopharm Therapeutics’ selinexor, Sanofi/ImmunoGen’s isatuximab, and Bluebird Bio/Celgene’s bb2121 are pursuing initial approvals for the treatment of multiple myeloma, highlighting that untapped clinical and commercial potential exists in multiple myeloma for therapies with improved efficacy, novel mechanisms of action, and positioned in patient segments that are currently underserved.

Questions Answered

  • Revlimid and Velcade are widely used for the current treatment of multiple myeloma, but how will the use of these agents change over the forecast period? What impact will generic entries of these pivotal agents have on the multiple myeloma market?
  • How has the approval of Janssen’s Darzalex and Bristol-Myers Squibb/AbbVie’s Empliciti impacted the multiple myeloma market? How important will these agents become over the forecast period?
  • What are thought-leaders’ opinions on agents in Phase III development, such as Merck & Co.’s Keytruda, Bristol-Myers Squibb/Ono Pharmaceutical’s Opdivo, Sanofi/ImmunoGen’s isatuximab, Bluebird Bio/Celgene’s bb2121, and GlaxoSmithKline’s GSK2857916? What impact will these agents have on the multiple myeloma market?
  • What are the drivers and constraints in the multiple myeloma market, and how will the market evolve over the forecast period?

Product Description

Disease Landscape & Forecast: Comprehensive market intelligence providing world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Table of contents

  • Disease Landscape & Forecast
    • Key Updates
      • December 2018
      • October 2018
      • September 2018
      • May 2018
      • March 2018
      • December 2017
    • Market Outlook
      • Key Findings
        • Key Findings
        • Market Overview
      • Market Drivers and Constraints
        • What Factors Are Driving the Market for Multiple Myeloma?
        • What Factors Are Constraining the Market for Multiple Myeloma?
      • Segment-Specific Trends
        • Smoldering Multiple Myeloma
        • First-Line Transplant-Eligible Multiple Myeloma
        • First-Line Transplant-Ineligible Multiple Myeloma
        • Relapsed/Refractory Multiple Myeloma
    • Forecast
    • Etiology and Pathophysiology
      • Disease Overview
      • Disease Pathophysiology
        • Overview
      • Risk Factors
      • Staging and Classification
        • Classification of Multiple Myeloma
        • Staging of Multiple Myeloma
      • Key Pathways and Drug Targets
    • Epidemiology
      • Key Findings
      • Epidemiology Populations
        • Diagnosed Incident Cases
        • Diagnosed Incident Cases of Multiple Myeloma by Symptoms
        • Asymptomatic Multiple Myeloma Progression to Symptomatic Multiple Myeloma
        • Drug-Treatable Populations
        • Drug-Treated Populations
    • Current Treatment
      • Key Findings
      • Treatment Goals
      • Key Current Therapies
        • Overview
        • Immunomodulatory Agents
        • Proteasome Inhibitors
        • Histone Deacetylase Inhibitors
        • Cell-Surface-Targeted Agents
      • Medical Practice
        • Asymptomatic Multiple Myeloma
        • First-Line Transplant-Eligible Multiple Myeloma
        • First-Line Transplant-Ineligible Multiple Myeloma
        • Relapsed/Refractory Multiple Myeloma
        • Treatment Guidelines
        • Region-Specific Treatment Practices
    • Unmet Need
      • Attainment of Unmet Needs
        • Current and Future Attainment of Unmet Needs in Multiple Myeloma
    • Emerging Therapies
      • Key Findings
      • Key Emerging Therapies
        • Notable Developments Among Key Emerging Therapies for Multiple Myeloma
        • Immune Checkpoint Inhibitors
        • Apoptosis-Inducing Agents
        • Cell-Surface-Targeted Agents
        • Selective Inhibitors of Nuclear Export
        • CAR T-Cell Therapies
        • Antibody-Drug Conjugates
      • Early-Phase Pipeline Analysis
        • Notable Developments in the Early-Phase Pipeline for Multiple Myeloma
    • Access and Reimbursement
      • Region-Specific Reimbursement Practices
        • United States
        • EU5
        • Japan
        • Looking for More?
    • Methodology
      • Bottom-Up Forecasting Overview
        • Patient Populations
        • Drug- and Regimen-Specific Assumptions
      • Bottom-Up Forecasting Assumptions
        • General Sources of Data
        • General Statements About Pricing
        • Dosing, Cycles of Therapy, and Compliance
        • Generic Erosion
        • Biosimilar Erosion
        • Out-Year Forecasting
        • Emerging Therapy Prices
      • Primary Market Research
        • Experts Interviewed
    • Appendix
      • Multiple Myeloma Bibliography

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  • Pub Date: November 2018
  • Author(s): Paul Wilcock. PhD; Nishant Kumar, MPH
  • Since October 2015, Dr. Wilcock has been a Business Insights Analyst in the oncology team at Decision Resources Group. He has experience in various indications including metastatic malignant melanoma and renal cell carcinoma, and will have a major focus on gastric cancer going forward. Previously, Dr. Wilcock was a Research Funding Manager at Cancer Research UK, where he developed a deep understanding of drug discovery, predominantly in the academic setting. He gained his doctorate from the University of Manchester where he utilized Systems Biology to explore the role of cell signaling and hypoxia in oral cancer.

  • Nishant is a senior epidemiologist and head of oncology within the epidemiology team at Decision Resources Group. He also covers some CNS diseases, including Alzheimer’s disease and dementia. His key interests are developing interactive patient flows, and modelling disease progression to forecast commercially relevant drug-treatable incident and prevalent populations. Nishant also spends a lot of time collaborating with clients to help answer more specific questions through custom work and consulting projects. His qualifications include an MSc in Public Health with specialization in epidemiology and statistics from King’s College London, and a BSc in Medical Studies from the University of Birmingham.

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