Last Updated 2 December 2013
Bevacizumab (Roche/Genentech/Chugai’s Avastin) is the only targeted agent approved for ovarian cancer (CaO). We anticipate robust growth in the CaO market over our forecast period owing to penetration of bevacizumab in nearly all segments of the CaO market and the entry of premium-priced targeted therapies, some from novel drug classes. Oncologists are enthusiastic in welcoming new market entrants offering increased improved efficacy and tolerability into their treatment armamentarium. With the number of targeted agents approved for CaO set to increase significantly over the forecast period, determining the optimal sequential treatment to ensure the greatest patient benefit will be a key challenge.
Markets covered: United States, France, Germany, Italy, Spain, United Kingdom, Japan.
Primary research: 29 country-specific interviews with experts; physician surveys fielded to approximately 30 physicians from each of the major markets who treat at least five CaO patients per month.
Epidemiology: Diagnosed Incident cases of epithelial ovarian cancer by stage at diagnosis (I-IIA, IIB-IIC, III, and IV).
Population segments in market forecast: Early-stage first-line, advanced-stage first-line, second-line platinum-sensitive, second-line platinum-resistant, third-line, fourth and subsequent lines.
Emerging therapies: Phase II: 23 drugs; Phase III: 10 drugs.
Market forecast features: Using a proprietary patient-flow model incorporating mortality, we forecast population sizes and drug sales for all patient segments through 2022.
Alternative market scenarios: (1) If emerging targeted agents and bevacizumab receive regulatory approval in the first-line advanced CaO setting in the United States (2) If therapies from a novel drug class in CaO disappoint in their Phase III trials and fail to gain regulatory approval in any market under study.