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In the past decade, tumor necrosis factor-alpha (TNF-α) inhibitors, AbbVie’s Humira and Amgen’s Enbrel, and Janssen’s interleukin (IL)-12/23 inhibitor Stelara have been leading the U.S. psoriasis biologics market. However, the recent wave of U.S. approvals for novel psoriasis agents Celgene’s Otezla (2014), Novartis’s Cosentyx (2015), and Eli Lilly’s Taltz (2016) is anticipated to substantially alter the market landscape. The oral agent Otezla has been successfully carving out a space in the psoriasis treatment algorithm in biologics-naive patients. The more-effective biologics, IL-17 inhibitors Cosentyx and Taltz, are threatening the first-line dominance of TNF-α inhibitors. With the recent and anticipated entry of biosimilars, marketers of psoriasis therapies will learn how they can best overcome the formulary and uptake challenges facing current and emerging therapies in this increasingly competitive market.
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