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The crowded U.S. rheumatoid arthritis (RA) market boasts nine different biologics representing five distinct drug classes, including the blockbuster tumor necrosis factor-alpha (TNF-α ) inhibitors, Amgen’s Enbrel, AbbVie’s Humira, and Janssen’s Remicade, as well as Pfizer’s oral Jak inhibitor, Xeljanz. Fueling more competition and pricing pressure, two infliximab biosimilars are now marketed in the United States (Pfizer/Celltrion’s Inflectra and Merck’s Renflexis). With the impending entry of additional Jak inhibitors, in particular Olumiant, and biosimilars of several other TNF and non-TNF biologics, marketers are faced with fierce competition and increasing challenges to gain favorable formulary position and market uptake.
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Maria Genco, is an analyst on the Immune and Inflammatory Disorders group at Decision Resources Group, primarily focusing on rheumatoid arthritis and axial spondyloarthritis. She has authored market research reports on the RA disease landscape and commercial outlook of drugs, unmet needs in RA, and market access and reimbursement for RA targeted therapies. Prior to joining Decision Resources, Dr. Genco received her and in neuroscience from Brandeis University and a in neuroscience from Wellesley College.