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NSCLC is one of the most dynamic oncology indications with multiple premium-priced, targeted therapies available. Increasing segmentation in this market by biomarker-driven approvals has led to improved efficacy outcomes for patients. However, increased costs due to the expanded use of branded agents is driving up the overall cost of treatment in many market segments. In an increasingly competitive and highly fragmented market, therapies that can secure favorable reimbursement will have a significant advantage. This A&R content provides key insights for navigating the NSCLC market access landscape in the United States. The performance of branded NSCLC agents are evaluated against the economic and clinical expectations of payers and physicians.