Arlington Medical Resources (AMR), a provider of premier market intelligence for the pharmaceutical and diagnostic imaging industries, finds that surveyed clinicians cite extended-spectrum beta-lactamase (ESBL)-producing E. coli and K. pneumoniae as the most concerning resistant pathogens in hospital-acquired gram-negative infections. These pathogens are resistant to commonly prescribed first-line antibiotics (e.g., penicillins, cephalosporins), and physicians must tailor therapy accordingly when managing these infections.

"With increasing antibiotic resistance among key gram-negative pathogens, beta-lactam/beta-lactamase inhibitors and carbapenems are used for their potent broad-spectrum activity against gram-negative pathogens, including resistant strains," said Lisa Arias, analyst. Physicians have several agents to choose from when prescribing empiric therapy for suspected gram-negative infections, but Pfizer's Zosyn is one of the leading agents prescribed for these infections. This beta-lactam/beta-lactamase inhibitor has experienced widespread success in the hospital setting owing to its broad-spectrum activity, coverage of Pseudomonas, and physician familiarity with it.

The new report entitled Hospital Anti-Infectives Insight Series: Gram-Negative Infections also finds that based on the increases in resistance rates among gram-negative infections, surveyed infectious disease specialists foresee several important changes in their prescribing patterns in the next five years. They anticipate increasing their prescribing of newer antibiotics such as Johnson & Johnson's Doribax and Pfizer's Tygacil, in addition to the other currently available carbapenems and the older agent colistin. Specialists also indicated that they would reduce their use of quinolones. These findings highlight specialists' concern regarding the need to increase prescribing of reserved agents to treat pathogens that are developing resistance to commonly used first- and even second-line agents.

About the Report

AMR's Hospital Anti-Infectives Insight Series: Gram-Negative Infections analyzes hospital antifungal prescribing patterns using AMR's comprehensive and highly detailed clinical data in conjunction with primary research and extensive understanding of emerging therapies and forecasts. This report contains U.S. data and examines the reasons behind physicians' product preferences, factors driving hospital antibiotic prescribing patterns and receptivity to emerging antifungals.

About AMR

AMR ( serves the market intelligence needs of the pharmaceutical and diagnostic imaging industries. Research includes clinical inpatient databases that directly link anti-infective drug with indication/procedure, formulary and stocking status tracking studies, drug purchasing audits and diagnostic imaging procedure volume/contrast media usage audits. AMR is a Decision Resources, Inc. company.

About Decision Resources, Inc.

Decision Resources, Inc. is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources, Inc. at

All company, brand or product names contained in this document may be trademarks or registered trademarks of their respective holders.

  Decision Resources   Christopher Comfort   781-296-2597 

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SOURCE: Arlington Medical Resources

CONTACT: Christopher Comfort of Decision Resources, +1-781-296-2597,

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