Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that surveyed cardiologists identify a therapy's effect on mortality as the attribute that most influences their prescribing decisions in the treatment of ST-elevation myocardial infarction (STEMI). Clinical data and the opinions of interviewed thought leaders indicate that The Medicines Company's Angiomax/Angiox has advantages in this attribute over Eli Lilly's ReoPro, the sales-leading agent in percutaneous coronary intervention (PCI) treatment of STEMI.

The new report entitled STEMI: Significant Opportunity Awaits Drugs That Can Reduce Mortality Rates also finds that an antiplatelet agent administered with stenting that is associated with lower rates of mortality and thrombocytopenia than ReoPro and less severe drug interactions would earn a substantial patient share in STEMI. According to surveyed U.S. and European cardiologists, this patient share would be 50 percent in the United States and 40 percent in Europe.

In 2008, Decision Resources' proprietary clinical gold standard for STEMI treated with PCI was Angiomax/Angiox. Based on available data and expert opinion, Angiomax/Angiox will retain gold-standard status for STEMI in 2017. While some therapies in development for the treatment of STEMI with PCI hold promise, most have efficacy, safety and tolerability, and/or delivery features that interviewed physicians indicate are inferior when compared with Angiomax/Angiox.

"Interviewed physicians regard Angiomax/Angiox as being highly efficacious because it is associated with significantly lower mortality rates than the standard PCI adjunctive therapy of unfractionated heparin and a glycoprotein IIb/IIIa inhibitor," said Decision Resources Analyst Jeremy Goldman, M.D. "This mortality reduction is associated with lower rates of bleeding with Angiomax/Angiox."

About the Report

STEMI: Significant Opportunity Awaits Drugs That Can Reduce Mortality Rates is a DecisionBase 2009 report. DecisionBase 2009 is a decision-support tool that provides in-depth analysis of unmet need, physician expectations of new therapies and commercial dynamics to help pharmaceutical companies optimize their investments in drug development.

The report can be purchased by contacting Decision Resources. Members of the media may request an interview with an analyst.

About Decision Resources

Decision Resources (www.decisionresources.com) is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources, Inc. company.

About Decision Resources, Inc.

Decision Resources, Inc. is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources, Inc. at www.DecisionResourcesInc.com.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

  For more information, contact:    Decision Resources               Decision Resources, Inc.   Christopher Comfort              Elizabeth Marshall   781-296-2597                     781-296-2563   ccomfort@dresources.com          emarshall@dresources.com 

First Call Analyst:
FCMN Contact:

SOURCE: Decision Resources

CONTACT: Christopher Comfort of Decision Resources, +1-781-296-2597,
ccomfort@dresources.com; or Elizabeth Marshall of Decision Resources, Inc.,
+1-781-296-2563, emarshall@dresources.com

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