Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, for the treatment of moderate to severe Alzheimer's disease, a combination therapy that delays nursing home admission at 19 months would earn 43 percent patient share, according to surveyed U.S. neurologists. In comparison, in Europe, such an agent would earn a slightly lower patient share of 30 percent, according to surveyed European neurologists. This lower share estimate is possibly a result of higher price sensitivity of European markets.

The new report entitled Alzheimer's Disease (Moderate to Severe): Significant Opportunity Awaits Novel Agents Offering Only Incremental Efficacy and Delivery Advantages also finds that the Pfizer/Medivation's Dimebon plus donepezil (Eisai/Pfizer's Aricept, Bracco's Memac) combination earns Decision Resources' proprietary clinical gold-standard status for the treatment of moderate to severe Alzheimer's disease in 2013, following Dimebon's approval for Alzheimer's disease in 2012. The Dimebon/donepezil combination has competitive advantages in efficacy--including effect on cognition, the highest-weighted efficacy outcome by surveyed neurologists--over the current gold standard combination donepezil plus memantine (Merz/Grupo Grunenthal's Axura/Akatinol, Lundbeck's Ebixa, Forest Laboratories' Namenda).

"Surveyed neurologists say that a therapy's effect on cognitive decline is the attribute that most influences their prescribing decisions in moderate to severe Alzheimer's disease," stated Decision Resources Analyst Matthew Winton, Ph.D. "Clinical data and the opinions of interviewed thought leaders indicate that the Dimebon plus donepezil combination has advantages over the sales-leading memantine plus donepezil combination on this attribute."

About the Report

Alzheimer's Disease (Moderate to Severe): Significant Opportunity Awaits Novel Agents Offering Only Incremental Efficacy and Delivery Advantages is a DecisionBase 2010 report. DecisionBase 2010 is a decision-support tool that provides in-depth analysis of unmet need, physician expectations of new therapies and commercial dynamics to help pharmaceutical companies optimize their investments in drug development.

About Decision Resources

Decision Resources ( is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources, Inc. company.

About Decision Resources, Inc.

Decision Resources, Inc. is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources, Inc. at

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  For more information, contact:    Gisselle Morales                             Elizabeth Marshall   Decision Resources                           Decision Resources, Inc.   781-296-2691                                 781-296-2563             

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SOURCE: Decision Resources

CONTACT: Gisselle Morales, Decision Resources, +1-781-296-2691,; or Elizabeth Marshall, Decision Resources, Inc.,

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