Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that surveyed gastroenterologists and hepatologists identify a therapy's effect on sustained virologic response in genotype 1 patients as the attribute that most influences their prescribing decisions in hepatitis C virus infection. Clinical data and the opinions of interviewed thought leaders indicate that the addition of Vertex/Janssen Pharmaceutica/Mitsubishi Tanabe's telaprevir or Schering-Plough's boceprevir to peginterferon/ribavirin provide advantages in this attribute over Roche's Pegasys (peginterferon-a-2a) plus ribavirin, the sales-leading treatment in the market.
The new report entitled Hepatitis C Virus: Protease and Polymerase Inhibitors on the Horizon to Revolutionize Treatment finds that a novel protease inhibitor that, when used in combination with peginterferon/ribavirin and achieves a significantly higher sustained virologic response in genotype 1 patients with only 24 weeks of treatment compared with the standard 48-week therapy with peginterferon/ribavirin, would earn a higher patient share in the United States than in Europe. The report finds that such an agent would earn a 60 percent patient share in the U.S. and a 40 percent patient share in Europe, according to surveyed U.S. and European gastroenterologists and hepatologists.
In 2008, Decision Resources' proprietary clinical gold standard for hepatitis C virus was Pegasys plus ribavirin because of its advantages in delivery and dosing. Based on available data and expert opinion, telaprevir plus ribavirin and a long-acting interferon will earn gold-standard status for hepatitis C virus following approval of telaprevir in 2011.
"New regimens that include a protease inhibitor, such as telaprevir or boceprevir, appear to have a competitive advantage in efficacy in patients infected with genotype 1 over the current peginterferon/ribavirin regimens," said Decision Resources Vice President John Lebbos, M.D. "Furthermore, the duration of therapy for genotype 1 patients can potentially be reduced with new three-drug regimens."
About the Report
Hepatitis C Virus: Protease and Polymerase Inhibitors on the Horizon to Revolutionize Treatment is a DecisionBase 2009 report. DecisionBase 2009 is a decision-support tool that provides in-depth analysis of unmet need, physician expectations of new therapies and commercial dynamics to help pharmaceutical companies optimize their investments in drug development.
The report can be purchased by contacting Decision Resources. Members of the media may request an interview with an analyst.
About Decision Resources
Decision Resources (www.decisionresources.com) is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources, Inc. company.
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