Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that Centocor/Schering-Plough/Mitsubishi Tanabe/Janssen's golimumab and Roche/Chugai's Actemra will be two of the most successful emerging novel agents in the rheumatoid arthritis drug market over the next decade in the United States, France, Germany, Italy, Spain, United Kingdom and Japan.

The new Pharmacor report entitled Rheumatoid Arthritis finds that the novel TNF-alpha inhibitor golimumab will be one of the most commercially successful emerging agents for rheumatoid arthritis, due to its more- convenient intravenous and subcutaneous dosing formulations, compared with the formulations of other current and emerging TNF-alpha inhibitors. Additionally, due to its novel mechanism of action, the interleukin-6 inhibitor Actemra will successfully compete with Bristol-Myers Squibb's Orencia and Biogen Idec/Genentech/Chugai/Zenyaku Kogyo's Rituxan / Roche's MabThera in the treatment of rheumatoid arthritis patients who respond inadequately to TNF-alpha inhibitors.

The report also finds that Amgen/Wyeth/Takeda's Enbrel and Abbott/Eisai's Humira -- both currently marketed TNF-alpha inhibitors -- will continue to dominate the rheumatoid arthritis market. Driven by their continued uptake as first-line treatments among biological agents, sales of Enbrel and Humira for rheumatoid arthritis will be close to $4 billion for each drug by 2017.

"Most of the sales growth over the next 10 years will occur through 2012, driven by continued uptake of currently marketed drugs and the launch of several novel biological agents," said Dancella Fernandes, Ph.D., analyst at Decision Resources. "From 2012 to 2017, annual market growth will slow due to fewer new product launches, restrictions imposed by third-party payers that will prevent expansion of biological therapy into earlier lines of treatment, biogeneric erosion and smaller increases in the rates of diagnosis and drug treatment."

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SOURCE: Decision Resources

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