Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that GlaxoSmithKline's Advair is positioned ahead of Boehringer Ingelheim/Pfizer's Spiriva in first and second lines of therapy for chronic obstructive pulmonary disease (COPD). Advair captures 55.3 percent of its total patients from first- and second-lines of therapy whereas Spiriva captures 51.4 percent. Advair also has higher patient shares in first- and second-line therapy in newly diagnosed patients.
"Although Advair is currently positioned just ahead of Spiriva in lines of therapy, over the next two years, we expect Spiriva use to grow more rapidly than Advair's use, and Spiriva may inch ahead of Advair in lines of therapy," stated Michael Malecki, Ph.D., analyst at Decision Resources. "In order to get ahead of Advair, Spiriva will need to see growing use among primary care physicians because a lot of Advair's use is driven by these physicians."
The new report entitled Treatment Algorithms in Chronic Obstructive Pulmonary Disease also finds that AstraZeneca's Symbicort-a combination inhaler in the same class as Advair-will be used more frequently in second-line therapy over the next two years. Symbicort is not yet FDA approved for COPD (the drug is preregistered for this indication), but it is approved for asthma.
"The net number of surveyed physicians who expect to increase their use of long-acting beta2 agonist (LABA)/inhaled corticosteroid (ICS) combinations such as Symbicort and Advair, in the second line is greater than those who have this expectation for the first line," added Dr. Malecki. "Because Advair already captures a larger share of the first line than any other single agent, and because more surveyed physicians indicate they will increase their second line use of Symbicort, we think growth of LABA/ICS inhalers in the first and second lines over the next two years will be driven primarily by uptake of Symbicort in these lines of therapy."
About Treatment Algorithm Insight Series
Decision Resources combines in-depth primary research with the most extensive claims-based longitudinal patient-level data from PharMetrics® to provide exceptional insight into physicians' prescribing trends and the factors that drive therapy product choice, from diagnosis through multiple courses of treatment, for a specific disease.
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