Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that a therapy's effect on incidence of mortality at 30 days is the attribute that most influences surveyed cardiologists' prescribing decisions in non-ST elevation myocardial infarction (NSTEMI). Data and the opinions of interviewed thought leaders indicate that current and emerging drugs, including Eli Lilly/Daiichi Sankyo's Efient, have no advantage in this attribute over The Medicines Company's Angiomax, the market sales leading agent.
The new report entitled NSTEMI: Finding the Balance between Efficacy and Safety finds that a drug that reduces mortality more than Angiomax at 30 days with significantly lower rates of bleeding would earn a 50 percent patient share in the United States and a 60 percent patient share in Europe, according to surveyed U.S. and European cardiologists. Angiomax, which was Decision Resources' proprietary clinical gold standard in 2008 for NSTEMI, will remain the clinical gold standard therapy and the market share leader through 2017, due to its efficacy and safety
The report finds that although some therapies in development for NSTEMI hold promise, most have either efficacy or safety and tolerability features that surveyed cardiologists rated inferior when compared with Angiomax. New agents in the market include Efient, which was approved by the European Medicines Agency in February 2009 for treatment of NSTEMI in the European Union.
"Angiomax has the most robust clinical data of drugs in its class for its use in NSTEMI and benefits from an immediate onset of action, which has driven physician usage and has enabled it to dominate the NSTEMI market," said Decision Resources Analyst Amir Mobasheri. "However, Efient and other emerging drugs such as AstraZeneca's ticagrelor, The Medicines Company's cangrelor and GlaxoSmithKline's Arixtra are not expected to achieve a market share as high as that of Angiomax, largely owing to safety or efficacy concerns."
About the Report
NSTEMI: Finding the Balance between Efficacy and Safety is a DecisionBase 2009 report. DecisionBase 2009 is a decision-support tool that provides in-depth analysis of unmet need, physician expectations of new therapies and commercial dynamics to help pharmaceutical companies optimize their investments in drug development.
The report can be purchased by contacting Decision Resources. Members of the media may request an interview with an analyst.
About Decision Resources
Decision Resources (www.decisionresources.com) is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources, Inc. company.
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